{"product_id":"abcam-ab222316","title":"Abcam, ab222316, Anti-PACS2 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal PACS2 antibody. Suitable for ICC\/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PACS2 aa 350-500.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human PACS2 aa 350-500. The exact immunogen used to generate this antibody is proprietary information.Q86VP3\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPACS2 also known as Phosphofurin Acidic Cluster Sorting Protein 2 functions as an integral membrane-associated sorting protein within cells. It weighs approximately 102 kDa. The protein is expressed widely with specific presence noted in the cytoplasm and mitochondria. Its role predominantly lies in modulating the trafficking and localization of various proteins contributing to cellular homeostasis and maintenance.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPACS2 regulates cellular death pathways and mitochondrial dynamics by balancing pro- and anti-apoptotic signals. It forms part of the larger regulatory complexes that modulate interactions between organelles particularly affecting endoplasmic reticulum-mitochondria communication. This regulation influences apoptosis autophagy and calcium signaling playing an important role in cellular health and stress responses.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe PACS2 protein plays significant roles in pathways such as calcium homeostasis and the mitochondrial apoptosis pathway. It interacts with proteins like Bax and Bak which are essential for apoptotic processes. PACS2's function directly impacts cellular survival pathways by modulating calcium transfer between the endoplasmic reticulum and mitochondria showing its importance in signal transduction and energy metabolism.\u003cbr\u003e\nPACS2 is connected to neurodegenerative diseases such as Alzheimer's disease and metabolic disorders like diabetes. In Alzheimer's the protein's dysregulation affects mitochondrial function and neuronal survival implicating it in the pathogenesis. It also interacts with proteins such as amyloid precursor protein in Alzheimer's highlighting its role in neurodegenerative disease processes. In diabetes altered PACS2 activity affects insulin signaling and mitochondrial function making it a potential target for therapeutic interventions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848598245545,"sku":"ab222316","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab222316","provider":"Iright","version":"1.0","type":"link"}