{"product_id":"abcam-ab222843","title":"Abcam, ab222843, Anti-Adenine Nucleotide Translocator 2\/ANT 2 antibody","description":"\u003cp\u003eSize: 50µL\u003cbr\u003e\nRabbit Polyclonal Adenine Nucleotide Translocator 2\/ANT 2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SLC25A5 aa 100-200.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human SLC25A5 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.P05141\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity \u0026gt;95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe Adenine Nucleotide Translocator 2 (ANT 2) also referred to as ANT protein or 2 ANT is an important component of the mitochondrial inner membrane. It belongs to the family of adenine nucleotide translocator proteins with a molecular weight of about 33 kDa. ANT 2 facilitates the exchange of ATP and ADP across the mitochondrial membrane. This protein is mainly expressed in tissues with high energy demand such as the heart liver and skeletal muscle.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nANT 2 functions to regulate cellular energy metabolism by controlling the exchange of adenine nucleotides between the mitochondria and cytosol. It is a part of the permeability transition pore complex which plays a role in maintaining mitochondrial membrane potential and preventing apoptosis. ANT 2 interacts with nucleotides to modulate energy production making it essential for the maintenance of cellular bioenergetics.\u003cbr\u003e\nPathways\u003cbr\u003e\nANT 2 integrates into significant energy production pathways including oxidative phosphorylation. It forms a functional unit with proteins like the voltage-dependent anion channel (VDAC) within the mitochondrial interface. This relationship with VDAC is key to ATP production and involves cellular energy transactions fundamental to numerous metabolic and signaling pathways.\u003cbr\u003e\nANT 2 demonstrates relevance to both cancer and cardiomyopathy. In cancer the overexpression of ANT 2 may support the high energy demands of rapidly proliferating cells. Meanwhile in cardiomyopathy mutations or dysregulation in ANT 2 impact energy metabolism leading to heart dysfunction. The interaction of ANT 2 with pro-apoptotic proteins like Bax influences the pathogenesis of these diseases by mediating mitochondrial-induced apoptosis.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850156036265,"sku":"ab222843","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab222843","provider":"Iright","version":"1.0","type":"link"}