{"product_id":"abcam-ab222894","title":"Abcam, ab222894, Anti-FBXL21\/FBL3 antibody","description":"\u003cp\u003eSize: 50µL\u003cbr\u003e\nRabbit Polyclonal FBXL21\/FBL3 antibody. Suitable for WB, IHC-P, ICC\/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FBXL21P aa 50-150.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:IHC-P, WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human FBXL21P aa 50-150. The exact immunogen used to generate this antibody is proprietary information.Q9UKT6\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity \u0026gt;95%., Storage buffer-pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nFBXL21 also known as FBL3 is a protein that functions as an E3 ubiquitin ligase which means it is involved in tagging proteins for degradation by the proteasome. FBXL21 belongs to the F-box protein family and contains an F-box domain that allows it to form part of a larger SCF (SKP1-Cullin-F-box) complex. This protein has a molecular mass of approximately 60 kDa. FBXL21 expresses in various tissues including the heart brain and skeletal muscle indicating its vital mechanical role across different physiological systems.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nFBXL21 plays a significant role in regulating circadian rhythms by modulating the stability of core clock proteins. It forms a complex with other proteins such as SKP1 and Cullin-1 to selectively ubiquitinate and degrade specific substrates. Its function is important in maintaining the balance between tau phosphorylation and degradation impacting the internal biological clock. Alterations in this process can significantly affect the organism's ability to adapt to the changes in light and dark cycles.\u003cbr\u003e\nPathways\u003cbr\u003e\nFBXL21 is involved in the circadian pathway regulating the oscillation of clock proteins such as CRY1 and CRY2 which control circadian stability. The protein interacts with pathways related to protein degradation and regulation of the protein levels ensuring timely degradation of phosphorylated clock proteins. FBXL21's interaction with the SCF complex components like SKP1 and Cullin-1 positions it as an essential player in these pathways coordinating the ubiquitin-proteasome system's role in maintaining cellular homeostasis.\u003cbr\u003e\nFBXL21's dysregulation relates to sleep disorders and potential links to neurodegenerative diseases like Alzheimer's. Disruptions in circadian rhythm proteins like CRY1 and CRY2 can result in altered sleep patterns and cognitive difficulties. Additionally improper FBXL21 function affects tau protein levels which links it to neurodegeneration and diseases associated with tauopathies. Understanding FBXL21's role can contribute to insights into managing circadian-based disorders and neurodegenerative conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854189875369,"sku":"ab222894","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab222894","provider":"Iright","version":"1.0","type":"link"}