{"product_id":"abcam-ab223269","title":"Abcam, ab223269, Anti-ASPA antibody [EPR22072]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nAnti-ASPA antibody [EPR22072] (ab223269) is a rabbit monoclonal antibody detecting ASPA in  Western Blot, IP, IHC-P, IHC-Fr . Suitable for  Human, Mouse, Rat . - Biophysical QC for unrivalled batch-batch consistency\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR22072,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:IHC-P, IP, IHC-Fr, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat is this antibody validated in?\u003cbr\u003e\nAnti-ASPA antibody [EPR22072] (ab223269) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC-P), Immunohistochemistry (IHC-Fr) in Human, Mouse, Rat samples.\u003cbr\u003e\nWhat is the molecular weight of ASPA?\u003cbr\u003e\nAnti-ASPA [EPR22072] (ab223269) specifically detects a band for ASPA (UniProt: P45381) at a molecular weight of 36kDa.\u003cbr\u003e\nTrial sizes available!\u003cbr\u003e\nTest your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl.\u003cbr\u003e\nDiscover our selection of trial-size antibodies\u003cbr\u003e\nOther related products\u003cbr\u003e\nWe have a range of other formats of antibody clone [EPR22072] also available for your convenience: ab223269, Carrier free -\u003cbr\u003e\nab239522\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAspartoacylase also known by its abbreviation ASPA is an enzyme that breaks down N-acetyl-L-aspartate into aspartate and acetate. It has a mass of about 60 kDa. ASPA is highly expressed in the brain especially in oligodendrocytes which are a type of central nervous system cell responsible for producing the myelin sheath that surrounds nerve cells. Its enzymatic activity is dependent on divalent metal ions which are required for its function.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nASPA plays an important role in myelin sheath maintenance and acetate metabolism. This protein doesn't form part of a complex but acts independently in the cytoplasm and peroxisomes of cells. Its function is significant for the provision of acetate for lipid synthesis which is necessary for myelin production. By regulating N-acetyl-L-aspartate levels in the brain ASPA activity is linked directly to protecting nerve cells' structural integrity.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe ASPA enzyme is involved in the aspartate and acetyl-CoA pathways which are central to cellular energy balance and lipid metabolism. Its enzymatic role facilitates the recycling of acetate which is vital to the synthesis of myelin lipids. The relationship of ASPA with enzymes like acetyl-CoA synthetase highlights its involvement in broader biochemical pathways fundamental to cell metabolism and growth.\u003cbr\u003e\nDeficiencies in ASPA are linked to Canavan disease a rare and inherited neurodegenerative condition characterized by white matter sponginess and loss of motor skills. This disorder results from mutations in the ASPA gene leading to dysfunctional enzyme activity. Additionally changes in ASPA expression levels might contribute to demyelinating disorders where proteins like myelin basic protein are also often involved making ASPA an important target for studies exploring nervous system diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844144779433,"sku":"ab223269","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab223269","provider":"Iright","version":"1.0","type":"link"}