{"product_id":"abcam-ab223602","title":"Abcam, ab223602, PFI-3, bromodomain and SMARCA4 inhibitor","description":"\u003cp\u003eSize: 5mg \/ 25mg\u003cbr\u003e\nMW 321.4 Da, Purity \u0026gt;98%. Potent and selective inhibitor of Polybromo (Kd = 48 nM) and SMARCA4 (K d  = 89 nM). Also inhibits SMARCA2. Displays high specificity for Family VIII bromodomains. PFI-3 displays selectivity against a range of other kinases. In a panel of 103 receptors and enzymes, activity was observed only against 4 GPCRs. At a concentration of 1 μM, PFI-3 accelerates FRAP recovery in cells.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:1819363-80-8,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:321.4 Da,\u003cbr\u003e\nMolecular formula:C19H19N3O2,\u003cbr\u003e\nPubChem:78243717,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nBiochemical name:(E)-1-(2-hydroxyphenyl)-3-((1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)prop-2-en-1-one,\u003cbr\u003e\nBiological description:Potent and selective inhibitor of Polybromo (Kd = 48 nM) and SMARCA4 (Kd = 89 nM). Also inhibits SMARCA2. Displays high specificity for Family VIII bromodomains. PFI-3 displays selectivity against a range of other kinases. In a panel of 103 receptors and enzymes, activity was observed only against 4 GPCRs. At a concentration of 1 μM, PFI-3 accelerates FRAP recovery in cells.,\u003cbr\u003e\nCanonical smiles:C1C2CN(C1CN2C3=CC=CC=N3)C=CC(=O)C4=CC=CC=C4O,\u003cbr\u003e\nIsomeric smiles:C1[C@@H]2CN([C@H]1CN2C3=CC=CC=N3)\/C=C\/C(=O)C4=CC=CC=C4O,\u003cbr\u003e\nInChi:InChI=1S\/C19H19N3O2\/c23-17-6-2-1-5-16(17)18(24)8-10-21-12-15-11-14(21)13-22(15)19-7-3-4-9-20-19\/h1-10,14-15,23H,11-13H2\/b10-8+\/t14-,15-\/m1\/s1,\u003cbr\u003e\nInChiKey:INAICWLVUAKEPB-QSTFCLMHSA-N,\u003cbr\u003e\nIUPAC Name:(E)-1-(2-hydroxyphenyl)-3-[(1R,4R)-5-pyridin-2-yl-2,5-diazabicyclo[2.2.1]heptan-2-yl]prop-2-en-1-one\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called 2895 PFI-3. 2895-25 is the same size as the 25 mg size of ab223602.\u003cbr\u003e\nProtect from air.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store in the dark\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847423283369,"sku":"ab223602","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab223602","provider":"Iright","version":"1.0","type":"link"}