{"product_id":"abcam-ab223661","title":"Abcam, ab223661, Anti-Integrin alpha 3 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nGoat Polyclonal Integrin alpha 3 antibody. Suitable for WB and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ITGA3 aa 1000-1050.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Goat,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human ITGA3 aa 1000-1050. The exact immunogen used to generate this antibody is proprietary information.P26006,\u003cbr\u003e\nSpecificity:This antibody is expected to recognize reported isoform a (NP_002195.1).\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nIntegrin alpha 3 also known as ITGA3 or alpha 3 is a protein that plays an important role in cell adhesion and signaling. It forms complexes with other integrins to mediate interactions between cells and the extracellular matrix. Integrin alpha 3 is a type I transmembrane protein with a molecular weight of approximately 120 kDa. This protein is primarily expressed in epithelial tissues including the skin kidneys and respiratory tract.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nIntegrin alpha 3 functions as a cell surface receptor that helps regulate cell migration proliferation and differentiation. It is a part of the alpha-3-beta-1 integrin complex which interacts with extracellular proteins like laminin-5 and collagen. This interaction facilitates the transmission of signals from the outside to the inside of the cell affecting various cellular responses and activities.\u003cbr\u003e\nPathways\u003cbr\u003e\nIntegrin alpha 3 plays a significant role in the cell signaling and communication pathways. It is involved in the pathways like focal adhesion and MAPK signaling. In these pathways integrin alpha 3 interacts with other proteins such as paxillin and FAK (focal adhesion kinase) which are critical for the downstream signaling that regulates cell shape and movement.\u003cbr\u003e\nIntegrin alpha 3 is linked to conditions like skin blistering diseases and cancers particularly those affecting the epithelial tissues. Alterations in integrin alpha 3 expression or function can disturb cell adhesion leading to diseases like epidermolysis bullosa. Additionally in cancer integrin alpha 3 often collaborates with proteins like MMP-9 to promote tumor invasion and metastasis.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854448349353,"sku":"ab223661","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab223661","provider":"Iright","version":"1.0","type":"link"}