{"product_id":"abcam-ab223718","title":"Abcam, ab223718, Anti-EMP2 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal EMP2 antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human EMP2 aa 1-100.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human EMP2 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.P54851\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe protein epithelial membrane protein 2 (EMP2) also known as EMP2 or emp002 has a mass of approximately 20 kDa. EMP2 is expressed mainly in epithelial cells and certain tissues including the lungs breast and reproductive tissues. It appears on the cell surface where it modulates several cell processes. EMP2 plays a role in cell surface configuration by influencing the localization of other critical membrane proteins.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nEMP2 influences the cell's ability to undergo endocytosis a process important for nutrient uptake and signal transduction. It is part of a multiprotein complex that interacts with integrin and caveolin which are essential for cellular adhesion and signaling. EMP2 impacts cellular communication and growth emphasizing its role in maintaining cellular homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nEMP2 is involved in the integrin-mediated pathway and the caveolae-mediated endocytosis pathway. It impacts integrin beta-1 (ITGB1) and c-Src kinase which are proteins important in cell signaling and mobility. These pathways facilitate various cellular functions including signal transmission and regulation of the cytoskeleton. EMP2's interaction with these pathways underlines its significance in cellular processes.\u003cbr\u003e\nEMP2 has connections to lung cancer and endometriosis. Its altered expression influences disease progression and is associated with metastatic potential. EMP2 acts in concert with proteins such as β-catenin and fibronectin which contribute to cancer development and cellular invasiveness. Understanding EMP2's role offers insights into potential therapeutic targets for these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854056313001,"sku":"ab223718","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab223718","provider":"Iright","version":"1.0","type":"link"}