{"product_id":"abcam-ab224223","title":"Abcam, ab224223, Anti-Syntaxin 7 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal Syntaxin 7 antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human STX7 aa 1-200.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WB, ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human STX7 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.O15400\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSyntaxin 7 also known as STX7 is a member of the SNARE protein family important for vesicle fusion processes. With a molecular mass of approximately 29 kDa Syntaxin 7 plays a significant role in the intracellular trafficking system by mediating membrane fusion events. It is expressed predominantly in many tissues including the brain and spleen where it contributes to diverse cellular functions. As a member of the target membrane SNARE proteins Syntaxin 7 partners with other SNARE proteins to facilitate endolysosomal transport.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSyntaxin 7 mediates membrane fusion events essential for endosome-lysosome fusion. It forms a complex with other SNARE proteins like Vti1b Syntaxin 8 and VAMP8. This complex orchestrates the accurate trafficking and degradation of macromolecules within cells. Syntaxin 7's presence proves essential in ensuring molecules are delivered to lysosomes for degradation and it participates in recycling cellular components. This role helps maintain cellular homeostasis by regulating the turnover of cellular substances.\u003cbr\u003e\nPathways\u003cbr\u003e\nSyntaxin 7 plays vital roles in processes related to vesicle transport and autophagy. It contributes significantly to the endocytic pathway an important pathway responsible for importing molecules into cells and directing them to lysosomes for breakdown. Syntaxin 7 is also involved in the autophagic-lysosomal pathway working in conjunction with proteins like Syntaxin 8 to facilitate autophagosome and lysosome fusion. Its coordination in these pathways highlights the importance of Syntaxin 7’s role in maintaining cellular health and balance.\u003cbr\u003e\nSyntaxin 7 has been linked to conditions related to defective lysosomal storage and neurodegenerative diseases. In Alzheimer’s disease for instance impaired endosomal and lysosomal functions are typical and dysfunction of proteins like Syntaxin 7 can exacerbate these issues. Similarly abnormal expression of Syntaxin 7 could contribute to neuronal loss observed in Alzheimer's disease. Its interaction with other SNARE proteins in this context suggests that targeting Syntaxin 7 and its complex could offer therapeutic potential for addressing related cellular dysfunctions in these disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854217531561,"sku":"ab224223","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab224223","provider":"Iright","version":"1.0","type":"link"}