{"product_id":"abcam-ab224324","title":"Abcam, ab224324, Anti-Kinectin 1 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal Kinectin 1 antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human KTN1 aa 150-350.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human KTN1 aa 150-350. The exact immunogen used to generate this antibody is proprietary information.Q86UP2\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nKinectin 1 also known as kinectin is a protein with a molecular mass of approximately 156 kDa. Predominantly located in the endoplasmic reticulum kinectin 1 functions as a membrane anchor for kinesin motors. This protein facilitates the movement of organelles along microtubules by binding to kinesin which is essential for intracellular transport. Kinectin 1 expression can be detected in various tissues but is notably high in the brain liver and kidney reflecting its involvement in critical cellular processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nKinectin 1 plays an important role in the organization of the cytoskeleton. It interacts with other cytoskeletal components and participates in the assembly of the Golgi apparatus. Kinectin 1 also forms part of the larger motor protein complex that includes kinesin light chains and other adaptors critical for vesicle-mediated transport. This complex is responsible for maintaining cellular homeostasis and efficient distribution of materials within the cell.\u003cbr\u003e\nPathways\u003cbr\u003e\nKinectin 1 is integral to the intracellular trafficking and signaling pathways. It is closely associated with the secretory and endocytic pathways both of which depend on accurate and timely transport of proteins and membranes. Kinectin 1 collaborates with proteins like kinesin and cytoplasmic dynein facilitating directional transport along microtubules. This interaction is vital for the proper functioning of cellular logistics and signaling cascades.\u003cbr\u003e\nResearch shows that kinectin 1 is connected to neurodegenerative diseases such as Alzheimer's. Disruption in its normal function or expression can lead to impaired intracellular transport contributing to the pathogenesis of such conditions. Additionally kinectin 1 interacts with kinesin motor proteins in processes that when dysregulated may relate to metabolic disorders impacting cellular energy distribution. Understanding these connections could inform therapeutic strategies for related diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854193086633,"sku":"ab224324","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab224324","provider":"Iright","version":"1.0","type":"link"}