{"product_id":"abcam-ab224564","title":"Abcam, ab224564, Anti-ENPP6 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal ENPP6 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ENPP6 aa 1-150.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human ENPP6 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.Q6UWR7\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nENPP6 also known as ectonucleotide pyrophosphatase\/phosphodiesterase family member 6 functions as a choline-specific glycerophosphodiester phosphodiesterase. This enzyme has a role in the hydrolysis of choline-containing phosphodiester substrates to produce choline and glycerophosphates. The molecular weight of ENPP6 is approximately 53 kDa. Expression of ENPP6 occurs largely in the brain particularly in oligodendrocytes as well as in other tissues like the liver and kidneys where it executes its enzymatic roles.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe enzyme facilitates the regulation of phospholipid metabolism by hydrolyzing lysophosphatidylcholine (LPC) and other similar phospholipids. ENPP6 is recognized for its activity against lysophosphatidic acid (LPA) and with roles in membrane lipid remodeling. Although ENPP6 does not form part of a larger complex its action impacts lipid signaling molecules thereby influencing cellular signaling and membrane dynamics.\u003cbr\u003e\nPathways\u003cbr\u003e\nIt significantly influences the lipid metabolic pathways and the choline metabolism in cancer (CHOL) pathway. ENPP6 plays a critical role in generating LPA from LPC which is part of the lipid signaling pathway that involves LPA as a signaling molecule. It interacts with proteins like LPAR1 and LPCAT1 which play roles in lipid signaling and remodeling pathways.\u003cbr\u003e\nThe dysregulation of ENPP6 has associations with metabolic and neurodegenerative conditions. Altered levels of ENPP6 activity are observed in Alzheimer's disease where its function may impact neuronal health due to imbalanced phospholipid levels. In cancer ENPP6 overactivity has correlations with cancer cell proliferation within the choline metabolism pathway. It connects to proteins such as APP and WNT5A in disease contexts playing roles in abnormal signaling and cellular alterations.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854249021609,"sku":"ab224564","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab224564","provider":"Iright","version":"1.0","type":"link"}