{"product_id":"abcam-ab225870","title":"Abcam, ab225870, Anti-DDX47 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal DDX47 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human DDX47 aa 400 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human DDX47 aa 400 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9H0S4\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nDDX47 also known as DEAD box protein 47 functions as a putative RNA helicase involved in the unwinding of RNA secondary structures. This protein weighing approximately 52 kDa contains the conserved D-E-A-D amino acid motif characteristic of DEAD box proteins. It expresses broadly across various tissues but shows significant levels in the nucleolus where it plays roles in nucleolar activities.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis protein participates in ribosome biogenesis by assisting in the maturation of ribosomal RNA. DDX47 as part of ribonucleoprotein complexes facilitates the cleavage of precursor rRNA which is necessary for the production of functional ribosomal subunits. This process is essential for maintaining high rates of protein synthesis in rapidly growing cells thereby influencing cellular growth and proliferation.\u003cbr\u003e\nPathways\u003cbr\u003e\nRNA metabolism and ribosome biogenesis include DDX47 as an important component. In these pathways it interacts with proteins such as NOP56 and NOLC1 which are integral to ribosomal RNA processing. Through its role in these pathways DDX47 influences transcriptional and translational regulation which are fundamental processes in cell physiology.\u003cbr\u003e\nAlterations in DDX47 expression link to cancer and ribosomopathies. Abnormal activity or dysregulation of DDX47 can affect cell proliferation contributing to tumorigenesis. This protein connects to oncogenic proteins such as MYC which is associated with cell cycle regulation and cancer progression. Understanding these interactions provides insights into how DDX47 may contribute to disease pathogenesis and presents potential diagnostic or therapeutic targets.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46853959975081,"sku":"ab225870","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab225870","provider":"Iright","version":"1.0","type":"link"}