{"product_id":"abcam-ab22673","title":"Abcam, ab22673, Anti-Proteasome 20S alpha + beta antibody","description":"\u003cp\u003eSize: 50µL\u003cbr\u003e\nAnti-Proteasome 20S alpha + beta antibody (ab22673) is a rabbit polyclonal antibody detecting Proteasome 20S alpha + beta in  Western Blot, IP, IHC-Fr, ICC\/IF . Suitable for  Human, Mouse, Rat, Saccharomyces cerevisiae . - Over 30 publications - Trusted since 2005\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, Saccharomyces cerevisiae, Rat, Mouse,\u003cbr\u003e\nApplications:IP, WB, IHC-Fr, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Cell preparation containing PSMA1 protein. The exact immunogen used to generate this antibody is proprietary information.P25786\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat is this antibody validated in?\u003cbr\u003e\nAnti-Proteasome 20S alpha + beta antibody (ab22673) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC-Fr), Immunocytochemistry\/immunofluorescence (ICC\/IF) in Human, Mouse, Rat, Saccharomyces cerevisiae samples.\u003cbr\u003e\nTrusted by the scientific community\u003cbr\u003e\nAnti-Proteasome 20S alpha + beta (ab22673) was first used in a scientific publication in 2005 and has been cited over 30 times in peer-reviewed journals.\u003cbr\u003e\nReviewed by scientists\u003cbr\u003e\nAnti-Proteasome 20S alpha + beta (ab22673) has over 5 independent reviews from customers.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Whole antiserum, Storage buffer-Preservative: 0.065% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe proteasome 20S alpha + beta sometimes referred to simply as the 20S proteasome consists of the catalytic core of the larger 26S proteasome complex. This core degrades ubiquitinated proteins in eukaryotic cells. The 20S proteasome has a barrel-like structure composed of 28 subunits arranged in four stacked rings. Each alpha and beta ring contains seven subunits with masses approximately ranging from 20 to 31 kDa. The proteasome 20S alpha + beta is expressed in the cytoplasm and nucleus of cells important for maintaining protein homeostasis by removing damaged or misfolded proteins as well as short-lived regulatory proteins.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe proteasome 20S alpha + beta plays a central role in protein degradation ensuring cellular function by regulating the concentration of specific proteins. It is an important component of the ubiquitin-proteasome system (UPS) a complex important for protein turnover. The 20S core particle combines with regulatory particles to form the 26S proteasome which recognizes and unfolds ubiquitinated proteins before translocation into the core for degradation. By controlling the half-life of critical proteins the proteasome influences cellular processes such as the cell cycle apoptosis and immune responses.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe ubiquitin-proteasome system including the proteasome 20S alpha + beta is integral to protein homeostasis and the cell cycle control pathway. It removes cyclins key regulators of cell cycle progression illustrating its regulatory function. Another significant pathway is the NF-kB signaling pathway where the proteasome degrades inhibitors to activate NF-kB a transcription factor involved in inflammation and immune responses. These pathways highlight the proteasome's relationship with proteins like cyclins and IkBa emphasizing its role in cellular regulation.\u003cbr\u003e\nProteasome dysfunction links to neurodegenerative diseases such as Parkinson's disease and certain cancers. Aberrations in proteasomal activity can result in the accumulation of toxic protein aggregates contributing to neurodegenerative processes. In cancers altered regulation of the proteasome may promote cell survival and proliferation. The proteasome is connected to proteins like alpha-synuclein in Parkinson’s disease and p53 a tumor suppressor in cancer highlighting its potential as a therapeutic target.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855695401129,"sku":"ab22673","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab22673","provider":"Iright","version":"1.0","type":"link"}