{"product_id":"abcam-ab228821","title":"Abcam, ab228821, Anti-IMUP antibody - C-terminal","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal IMUP antibody. C-terminal. Suitable for IP and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human IMUP aa 50 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human IMUP aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9GZP8\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab228821 was affinity purified using an epitope specific to IMUP immobilized on solid support., Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe IMUP protein also known as C19orf33 has a molecular weight of approximately 17 kDa. This small protein is expressed in various tissues across the human body with noticeable levels in immune-related tissues like the spleen and lymph nodes. The specific cellular localization and expression patterns suggest a role in the immune system's functions. Researchers frequently investigate it to understand its potential interactions and effects better.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nIMUP participates in immune system regulation and cellular processes. It does not operate alone but forms part of a protein complex that influences immune responses. This complex is critical in recognizing and responding to foreign antigens aiding the immune system in distinguishing between self and non-self entities. The protein's involvement in cellular signaling pathways indicates its role in managing cell communication and response to environmental changes.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe IMUP protein plays roles within immune signaling and inflammatory pathways. For example immune response pathways such as the NF-kB pathway involve IMUP as a modulator. Proteins like TNF-alpha interact closely with IMUP influencing its role in signaling processes that regulate inflammation and cellular survival. These interactions highlight its importance in immune response regulation and complex signaling networks.\u003cbr\u003e\nIMUP is associated with autoimmune diseases and chronic inflammatory conditions. Researchers have identified its altered expression in autoimmune disorders such as rheumatoid arthritis where it's implicated in the disease's pathogenesis. It interacts with proteins like IL-6 which are known to contribute to the inflammatory environment characteristic of these conditions. Understanding IMUP's involvement in such diseases may offer insights into potential therapeutic targets and treatment strategies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46860697370793,"sku":"ab228821","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab228821","provider":"Iright","version":"1.0","type":"link"}