{"product_id":"abcam-ab229136","title":"Abcam, ab229136, Anti-OASL antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal OASL antibody. Suitable for WB, IHC-P, ICC\/IF and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Recombinant Fragment Protein within Human OASL.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human OASL. The exact immunogen used to generate this antibody is proprietary information.Q15646\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nOASL also known as 2'-5'-oligoadenylate synthetase-like protein functions mechanically by enhancing antiviral defense mechanisms. This protein weighs approximately 58 kDa and is expressed in various cell types including immune cells such as monocytes and lymphocytes. OASL belongs to the family of interferon-stimulated genes and shares structural similarities with other 2'-5'-oligoadenylate synthetases.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nOASL plays a significant role in the immune system's response to viral infections. It does not form a complex but aids in the synthesis of 2'-5'-linked oligoadenylates which activate RNase L leading to the degradation of viral RNA. By doing so OASL helps to restrict viral replication and propagation within the host organism strengthening the antiviral response.\u003cbr\u003e\nPathways\u003cbr\u003e\nOASL is actively involved in the interferon signaling pathway and the innate immune response pathway. It works closely with other proteins such as RIG-I-like receptors which are essential for detecting viral RNA and triggering downstream signaling processes. These interactions highlight OASL's integral function in coordinating antiviral defense strategies within these pathways.\u003cbr\u003e\nOASL has connections to viral infections and autoimmune disorders. During infections by viruses like hepatitis C OASL contributes to the host's defense by limiting viral replication. Additionally its involvement in autoimmune conditions such as systemic lupus erythematosus demonstrates its role in immune system regulation. In these contexts OASL associates with proteins like MAVS which facilitate innate immune signaling and modulate disease mechanisms.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854134333609,"sku":"ab229136","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab229136","provider":"Iright","version":"1.0","type":"link"}