{"product_id":"abcam-ab229181","title":"Abcam, ab229181, CCG 1423, Rho pathway-mediated signaling inhibitor","description":"\u003cp\u003eSize: 5mg \/ 25mg\u003cbr\u003e\nMW 454.7 Da, Purity \u0026gt;98%. Specific inhibitor of Rho pathway-mediated signaling and activation of serum response factor (SRF) transcription. Displays activity in several in vitro cancer cell functional assays. Potently (\u0026lt;1 mumol\/L) inhibits lysophosphatidic acid-induced DNA synthesis in PC-3 prostate cancer cells, inhibits growth of RhoC-overexpressing melanoma lines at nanomolar concentrations. Selectively stimulates apoptosis of the metastasis-prone, RhoC-overexpressing melanoma cell lines. Acts at or downstream of MLK1 and upstream of SRF. Blocks MLK1 nuclear localization.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:285986-88-1,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:454.7 Da,\u003cbr\u003e\nMolecular formula:C18H13ClF6N2O3,\u003cbr\u003e\nPubChem:2726015,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 100 mM,\u003cbr\u003e\nBiochemical name:n-(2-(4-Chloroanilino)-1-methyl-2-oxoethoxy)-3,5-bis(trifluoromethyl)benzamide,\u003cbr\u003e\nBiological description:Specific inhibitor of Rho pathway-mediated signaling and activation of serum response factor (SRF) transcription. Displays activity in several in vitro cancer cell functional assays. Potently (\u0026lt;1 mumol\/L) inhibits lysophosphatidic acid-induced DNA synthesis in PC-3 prostate cancer cells, inhibits growth of RhoC-overexpressing melanoma lines at nanomolar concentrations. Selectively stimulates apoptosis of the metastasis-prone, RhoC-overexpressing melanoma cell lines. Acts at or downstream of MLK1 and upstream of SRF. Blocks MLK1 nuclear localization.,\u003cbr\u003e\nCanonical smiles:CC(C(=O)NC1=CC=C(C=C1)Cl)ONC(=O)C2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F,\u003cbr\u003e\nInChi:InChI=1S\/C18H13ClF6N2O3\/c1-9(15(28)26-14-4-2-13(19)3-5-14)30-27-16(29)10-6-11(17(20,21)22)8-12(7-10)18(23,24)25\/h2-9H,1H3,(H,26,28)(H,27,29),\u003cbr\u003e\nInChiKey:DSMXVSGJIDFLKP-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:N-[1-(4-chloroanilino)-1-oxopropan-2-yl]oxy-3,5-bis(trifluoromethyl)benzamide\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called 9434 CCG-1423. 9434-25 is the same size as the 25 mg size of ab229181.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store in the dark, Store under desiccating conditions\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847424037033,"sku":"ab229181","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab229181","provider":"Iright","version":"1.0","type":"link"}