{"product_id":"abcam-ab229195","title":"Abcam, ab229195, Anti-TIE1 (phospho Y1007) + TIE2 (phospho Y992) antibody [EPR1053(N)(B)] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal TIE2 phospho Y992 antibody. Carrier free. Suitable for Dot, WB, ICC\/IF and reacts with Synthetic peptide, Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR1053(N)(B),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WB, DotSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:ab151704 only detects TIE1 phosphorylated at tyrosine 1007 and TIE2 phosphorylated at tyrosine 992.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab229195 is the carrier-free version of\u003cbr\u003e\nab151704\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTIE1 and TIE2 also known as Tyrosine Kinase with Immunoglobulin and EGF homology domains 1 and 2 are receptor tyrosine kinases. TIE1 has a molecular mass of roughly 130 kDa while TIE2 is about 145 kDa. These receptors express mainly in endothelial cells and they localize on the cell surface. Their structure allows them to bind specific ligands leading to signal transduction that influences cell behaviors.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThese receptors play significant roles in vascular development and maintenance. TIE1 and TIE2 form a complex with angiopoietins a group of growth factors important for blood vessel maturation and stability. The interactions between TIE receptors and angiopoietins control processes like endothelial cell survival migration and permeability making them essential for normal and pathological angiogenesis.\u003cbr\u003e\nPathways\u003cbr\u003e\nTIE1 and TIE2 receptors feature prominently in the angiogenesis pathway and the endothelial cell signaling pathway. They interact closely with the angiopoietin family and influence downstream signaling through pathways involving proteins like PI3K\/Akt and ERK\/MAPK. These pathways are important for regulating endothelial cell functions linking TIE receptors to the maintenance of vascular integrity and response to environmental cues.\u003cbr\u003e\nDisruptions in TIE1 and TIE2 signaling associate with conditions like cancer and cardiovascular disease. Aberrant TIE2 signaling correlates with tumor angiogenesis and metastasis often involving interactions with VEGF another key angiogenic factor. The dysfunction of these receptors may also contribute to atherosclerosis where improper endothelial cell communication leads to vascular inflammation and plaque formation. Understanding these connections aids in developing targeted therapies for managing such diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851833331881,"sku":"ab229195","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab229195","provider":"Iright","version":"1.0","type":"link"}