{"product_id":"abcam-ab229498","title":"Abcam, ab229498, Anti-Glutamyl Prolyl tRNA synthetase\/PARS antibody - C-terminal","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal Glutamyl Prolyl tRNA synthetase\/PARS antibody. C-terminal. Suitable for IP, WB, IHC-P and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human EPRS1.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:IP, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human EPRS1. The exact immunogen used to generate this antibody is proprietary information.P07814\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.025% Proclin 300Constituents: PBS, 20% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGlutamyl Prolyl tRNA synthetase also known as PARS is an enzyme that attaches specific amino acids to their corresponding tRNA molecules a process known as aminoacylation. This feature enables accurate translation of genetic code into proteins. PARS weighs around 170 kDa and exists in both prokaryotic and eukaryotic organisms. The expression of PARS is ubiquitous present in various tissues indicating its essential role in protein synthesis across different cells.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe enzyme is an important component in the process of protein synthesis. PARS activates and links glutamate and proline to tRNAs enabling the assembly line of protein production. This enzyme does not function alone; it functions as part of a larger multiprotein complex and interacts directly with the ribosomal machinery facilitating the incorporation of specific amino acids during the elongation phase of protein synthesis.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe enzyme plays an important role in the aminoacyl-tRNA biosynthesis pathway a critical process for maintaining the fidelity of protein synthesis. Within this pathway PARS works closely with other aminoacyl-tRNA synthetases to ensure that each tRNA is charged with the correct amino acid. This network of acylation and protein translation ties PARS to ribosomal proteins which are important for the synthesis process as well as to other enzymes involved in translational regulation.\u003cbr\u003e\nPARS mutations are linked to neurological disorders particularly Charcot-Marie-Tooth disease a condition characterized by nerve damage. Disruptions in PARS function may interfere with protein synthesis leading to defective cellular functions and disease progression. Also impaired function of PARS has a connection with cancer as alterations in protein synthesis pathways can drive uncontrolled cell growth. In cancer PARS may interact with oncogenes and other synthetases potently affecting tumorous growth and metastasis.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46853977374889,"sku":"ab229498","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab229498","provider":"Iright","version":"1.0","type":"link"}