{"product_id":"abcam-ab229938","title":"Abcam, ab229938, Anti-GNAZ antibody","description":"\u003cp\u003eSize: 50µL\u003cbr\u003e\nRabbit Polyclonal GNAZ antibody. Suitable for IHC-P, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Guanine nucleotide-binding protein G(z) subunit alpha aa 1-150.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human Guanine nucleotide-binding protein G(z) subunit alpha aa 1-150. The exact immunogen used to generate this antibody is proprietary information.P19086\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity \u0026gt;95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGNAZ also known as Guanine nucleotide-binding protein G(z) subunit alpha functions as a modulator or transducer in various transmembrane signaling systems. The protein plays an essential role in coupling cell surface receptors to intracellular signaling pathways. GNAZ weighs approximately 41.5 kDa and is widely expressed in human brain tissues and certain neuroendocrine tissues.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGNAZ connects with receptor-mediated signal transduction aiding in neurotransmitter release and sensory perception. GNAZ functions as part of the heterotrimeric G-protein complex which includes G beta and G gamma subunits. This protein often regulates signal transduction cascades that influence cellular responses to external stimuli.\u003cbr\u003e\nPathways\u003cbr\u003e\nGNAZ is closely linked to important signaling pathways such as the serotonergic signaling pathway and the phototransduction pathway. Within these pathways GNAZ interacts with kinases and ion channels influencing cellular responses and synaptic functions. GNAZ works alongside related proteins such as GNAI and GNAT contributing to the regulation of neurotransmitter systems.\u003cbr\u003e\nGNAZ relates to neurological disorders and certain psychiatric conditions including schizophrenia and bipolar disorder. Changes in the activity or expression of GNAZ may impact neurotransmitter systems which are fundamental to these conditions. Through these disorders GNAZ connects with proteins like GNB and GNG pointing to its involvement in signal processing abnormalities that underlie these diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854106808489,"sku":"ab229938","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab229938","provider":"Iright","version":"1.0","type":"link"}