{"product_id":"abcam-ab229965","title":"Abcam, ab229965, Anti-ANP32D antibody","description":"\u003cp\u003eSize: 50µL\u003cbr\u003e\nRabbit Polyclonal ANP32D antibody. Suitable for IHC-P, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ANP32D.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human ANP32D.O95626\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity \u0026gt; 95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nANP32D also known as acidic nuclear phosphoprotein 32 family member D is a protein involved in various cellular processes. It has a molecular weight of approximately 32 kDa. The protein is expressed broadly with notable levels in the nucleus and cytoplasm of diverse cell types. ANP32D functions in modulating chromatin dynamics and may influence transcriptional regulation and cellular signaling. Additionally it contributes to cellular processes like apoptosis and cell cycle progression due to its interaction with multiple signaling molecules and chromatin modifiers.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nProteins like ANP32D are important in the regulation of gene expression and maintenance of chromatin structure. It often functions as part of larger protein complexes integrating signals that dictate chromatin remodeling and transcriptional responses. ANP32D interacts with histone-binding proteins contributing to the dynamic changes in chromatin architecture required for gene expression and cellular responses. Its role in such complexes highlights its impact on processes like embryonic development and cellular differentiation.\u003cbr\u003e\nPathways\u003cbr\u003e\nVarious proteins work together with ANP32D impacting important biological systems like the MAPK signaling pathway and the apoptosis regulation pathway. ANP32D interacts with factors like histone deacetylases playing a part in signal transduction and transcriptional repression. The protein's involvement in these pathways suggests that it helps mediate cellular responses to external stimuli and internal cues coordinating cellular growth division and programmed cell death.\u003cbr\u003e\nResearch has linked ANP32D to cancer and neurodegenerative conditions. Its expression often changes in tumor tissues associating ANP32D with cancer progression and development. Altered levels of ANP32D as well as its interaction with proteins like PP2A can impact cellular proliferation and survival contributing to oncogenic processes. Its potential role in neurodegenerative disorders though less explored suggests ANP32D's involvement in cellular pathways affecting neuron survival and function highlighting its importance in disease mechanisms.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854229917865,"sku":"ab229965","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab229965","provider":"Iright","version":"1.0","type":"link"}