{"product_id":"abcam-ab230013","title":"Abcam, ab230013, Anti-MOCS2 antibody","description":"\u003cp\u003eSize: 50µL\u003cbr\u003e\nRabbit Polyclonal MOCS2 antibody. Suitable for IP, WB, IHC-P, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human MOCS2.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WB, IHC-P, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human MOCS2.O96007\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMOCS2 also known as molybdenum cofactor synthesis 2 plays a mechanical role in the biosynthesis of molybdenum cofactor. The protein has a molecular mass of approximately 20 kDa. MOCS2 is mainly expressed in the liver and kidneys where it contributes to various cellular processes. It consists of two isoforms A and B which play unique roles in facilitating the conversion of precursor molecules into active cofactors.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe molybdenum cofactor synthesis process requires several components to function effectively. MOCS2 is part of the molybdenum cofactor synthesis complex which is essential for proper enzyme activity that utilizes the molybdenum cofactor. Enzymes requiring this cofactor include xanthine oxidase and aldehyde oxidase both of which are critical for metabolizing purines and aldehydes. The formation and regulation of this complex ensure efficient enzyme activity across different tissues.\u003cbr\u003e\nPathways\u003cbr\u003e\nMOCS2 participates in the molybdenum cofactor biosynthesis pathway. It aligns with the sulfur transfer pathway where it interacts closely with MOCS1 another molybdenum cofactor synthesis protein. Both proteins coordinate to ensure sufficient cofactor production for catalytic reactions. These interactions allow for the proper function of enzymes like sulfite oxidase linking MOCS2 to essential metabolic processes.\u003cbr\u003e\nMutations or dysfunction in MOCS2 can lead to molybdenum cofactor deficiency a rare metabolic disorder. This disorder results in neurological symptoms due to the accumulation of toxic substances unmetabolized due to insufficient cofactor. MOCS2’s relationship with MOCS1 is significant as alterations in either can cause similar metabolic disruptions leading to the disease. Understanding MOCS2's role in these pathways provides insights into therapeutic strategies for affected individuals.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46853944311977,"sku":"ab230013","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab230013","provider":"Iright","version":"1.0","type":"link"}