{"product_id":"abcam-ab230509","title":"Abcam, ab230509, Anti-MT-ND5 antibody","description":"\u003cp\u003eSize: 200µL\u003cbr\u003e\nRabbit Polyclonal MT-ND5 antibody. Suitable for WB, IHC-P, Flow Cyt (Intra) and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human MT-ND5 conjugated to Keyhole Limpet Haemocyanin.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:Flow Cyt (Intra), IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human MT-ND5 conjugated to Keyhole Limpet Haemocyanin.P03915\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMT-ND5 also known as NADH-ubiquinone oxidoreductase chain 5 is a subunit of mitochondrial complex I found in the inner mitochondrial membrane. This protein weighing approximately 74 kDa plays a central role in the electron transport chain facilitating the transfer of electrons from NADH to ubiquinone. Expression of MT-ND5 occurs ubiquitously in tissues with high energy demands such as the heart brain and skeletal muscle where efficient ATP production is essential.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMT-ND5 functions as an integral component of mitochondrial complex I which is the first enzyme complex in the electron transport chain. By participating in this complex MT-ND5 contributes to the generation of a proton gradient across the inner mitochondrial membrane driving ATP synthesis through oxidative phosphorylation. Malfunction of MT-ND5 impairs energy production which can lead to a cascade of cellular energy deficiencies given its role within the complex.\u003cbr\u003e\nPathways\u003cbr\u003e\nMT-ND5 associates with the oxidative phosphorylation pathway. It is important for maintaining aerobic energy production by linking NADH oxidation with ubiquinone reduction. Other proteins like MT-ND1 and MT-ND4L also participate in electron transport chain pathways working alongside MT-ND5 to ensure effective electron transfer and mitochondrial respiration. Its function within these pathways highlights its importance in metabolic regulation.\u003cbr\u003e\nMT-ND5 mutations have associations with mitochondrial disorders such as Leigh syndrome and mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS). Defective MT-ND5 affects the electron transport chain leading to energy metabolism disruption in affected tissues. These disorders often involve other mitochondrial proteins such as MT-ND1 where combined mutations further exacerbate the dysfunction of mitochondrial capacity and highlight the profound impact on human health.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854032261289,"sku":"ab230509","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab230509","provider":"Iright","version":"1.0","type":"link"}