{"product_id":"abcam-ab230513","title":"Abcam, ab230513, Anti-HOXA1 antibody","description":"\u003cp\u003eSize: 50µL\u003cbr\u003e\nRabbit Polyclonal HOXA1 antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human samples. Cited in 12 publications. Immunogen corresponding to Synthetic Peptide within Human HOXA1 conjugated to Keyhole Limpet Haemocyanin.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human HOXA1 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.P49639\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.3Preservative: 0.01% Sodium azideConstituents: PBS, 30% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nHOXA1 also known as homeobox protein Hox-A1 is a transcription factor composed of 36 kDa. It contains a conserved DNA-binding domain known as the homeodomain. HOXA1 is encoded by the HOXA1 gene part of the Hox gene family responsible for regulating gene expression during early embryonic development. It gets expressed in specific regions during various developmental stages particularly contributing to the formation of the hindbrain and spinal cord. HOXA1 plays a significant role in controlling morphogenesis and differentiation processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe transcription factor regulates critical developmental processes by influencing the expression of genes involved in anterior-posterior patterning. HOXA1 functions within a complex involving other HOX proteins ensuring precise spatial and temporal gene regulation during development. This regulation facilitates the establishment of distinct body structures and organ systems as the embryo progresses. HOXA1 participates in defining boundaries and segmental structures in embryonic tissues.\u003cbr\u003e\nPathways\u003cbr\u003e\nHOXA1 impacts the retinoic acid signaling pathway and the Notch signaling pathway. It plays a significant role in the retinoic acid signaling axis influencing cell differentiation by modulating retinoid-responsive elements. In the Notch signaling pathway HOXA1 interacts with genes that control cell fate decisions often working in concert with other HOX proteins like HOXB1 and HOXD1. This involves activating downstream effectors vital for embryonic patterning and neurogenesis.\u003cbr\u003e\nResearchers have linked HOXA1 dysregulation to certain congenital defects and cancers. It associates with congenital conditions such as Bosley-Salih-Alorainy syndrome characterized by abnormalities in facial and cranial nerves alongside problems with hearing and cardiovascular development. In cancer aberrant HOXA1 expression has been observed linking to breast cancer progression hinting at its involvement in tumorigenesis. These connections often involve interactions with proteins such as PAX1 in congenital abnormalities and ERBB2 in cancer highlighting the need for therapeutic explorations targeting these pathways.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854124961961,"sku":"ab230513","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab230513","provider":"Iright","version":"1.0","type":"link"}