{"product_id":"abcam-ab230845","title":"Abcam, ab230845, Anti-SLC16A11 antibody","description":"\u003cp\u003eSize: 200µL\u003cbr\u003e\nRabbit Polyclonal SLC16A11 antibody. Suitable for WB, IHC-P, Flow Cyt (Intra) and reacts with Mouse, Human samples. Immunogen corresponding to Synthetic Peptide within Human SLC16A11 aa 1-100 conjugated to Keyhole Limpet Haemocyanin.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:IHC-P, WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human SLC16A11 aa 1-100 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q8NCK7\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSLC16A11 also known as monocarboxylate transporter 11 is a member of the solute carrier family. It has a mass of approximately 55 kDa. This transporter is primarily found in liver and adipose tissues where it likely functions in the transport of monocarboxylates such as lactate and pyruvate across cellular membranes. Its expression is notable in cells that are involved in energy metabolism.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSLC16A11 plays an important role in cellular metabolism. It facilitates the uptake and release of key metabolic intermediates. While there is no evidence that it forms a complex with other proteins it likely interacts with other monocarboxylate transporters in regulating cellular metabolic balance. The transporter's activity is particularly significant in contexts where shifts in cellular energy states require precise control over monocarboxylate levels.\u003cbr\u003e\nPathways\u003cbr\u003e\nSeveral processes involve SLC16A11 including energy metabolism and insulin signaling. It contributes to homeostatic metabolic pathways by modulating the availability of substrates for energy production. SLC16A11 works alongside other transporters such as SLC16A1 coordinating the movement of energy-related compounds. This regulation is key in maintaining metabolic stability especially under varying metabolic demands.\u003cbr\u003e\nSLC16A11 has a strong connection to type 2 diabetes. Genetic variants in this transporter are associated with altered risk of developing the condition particularly in certain populations such as those with Latin American ancestry. Other proteins like insulin receptor substrate 1 (IRS1) may interact indirectly with SLC16A11 impacting signaling pathways that control blood glucose levels. Research continues to investigate its role in metabolic diseases hoping to discover therapeutic targets or strategies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854034555049,"sku":"ab230845","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab230845","provider":"Iright","version":"1.0","type":"link"}