{"product_id":"abcam-ab233521","title":"Abcam, ab233521, Anti-PKIB antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal PKIB antibody. Suitable for WB, IHC-P and reacts with Human, Mouse samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PKIB aa 1 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human PKIB aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9C010\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Antigen-specific affinity chromatography followed by Protein A affinity chromatography., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 55.77% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPKIB or Protein Kinase Inhibitor Beta acts as an inhibitor for protein kinase A (PKA). It belongs to the family of PKI proteins that include PKIA and PKIG. PKIB contributes to the cellular process by binding to PKA and preventing its activity therefore affecting its downstream effects. PKIB has a molecular mass of approximately 9 kDa. It expresses predominantly in tissues such as the prostate and brain reflecting its specific roles in different cellular contexts.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe inhibition of PKA by PKIB plays a role in regulating cellular proliferation and apoptosis. PKIB does not form part of a larger complex but functions through direct interactions with its target PKA. PKIB's inhibitory action on PKA can modulate several downstream signalling cascades affecting various cellular outcomes according to the cellular context and signals received.\u003cbr\u003e\nPathways\u003cbr\u003e\nPKIB impacts key signalling networks such as the cAMP-dependent PKA pathway and the MAPK\/ERK pathway. PKIB's interaction with PKA affects the transduction of signals initiated by cyclic AMP which influences cellular processes diversity. PKIB assists in the modulation of MAPK\/ERK pathway working in concert with other proteins like AKAPs that organize PKA signaling compartments allowing for refined control over cellular responses to signaling.\u003cbr\u003e\nPKIB emerges as relevant in prostate cancer and certain neurological disorders. The association of PKIB with prostate cancer arises from the deregulation of PKA activity affecting cell proliferation and survival. Through interactions with other signaling proteins like CREB dysregulated PKIB expression might contribute to the pathology of cancer. Furthermore altered PKIB expression patterns have also been observed in neurological disorders where imbalanced kinase activities disrupt normal brain function.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848590184617,"sku":"ab233521","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab233521","provider":"Iright","version":"1.0","type":"link"}