{"product_id":"abcam-ab235003","title":"Abcam, ab235003, Anti-MYO5A antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal MYO5A antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MYO5A aa 1050-1250.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human MYO5A aa 1050-1250. The exact immunogen used to generate this antibody is proprietary information.Q9Y4I1\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity \u0026gt;95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMyosin Va also known as MYO5A is a motor protein with a mass of approximately 220 kDa. It plays an important role in intracellular transport by moving along actin filaments. This protein has two motor heads that use ATP hydrolysis to generate force for movement. MYO5A is widely expressed in a variety of tissues including the brain melanocytes and other neuronal tissues. It is vital for processes such as organelle transport vesicle trafficking and the distribution of melanin.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis protein acts as a cargo transporter within cells moving materials to specific destinations. It can form a complex with Rab27A aiding in the transport of organelles like melanosomes and synaptic vesicles. In neurons MYO5A contributes to synaptic function by ensuring the proper localization of neurotransmitter-containing vesicles. Its role in pigment-producing cells is critical for the even distribution of melanin which is important for skin and hair color.\u003cbr\u003e\nPathways\u003cbr\u003e\nMYO5A participates in the melanosome transport pathway and the neuroplasticity pathway. In the melanosome transport pathway it collaborates with the Rab27A and melanophilin proteins to ensure proper melanosome localization within melanocytes. This pathway is important for pigmentation. In the context of neuroplasticity MYO5A interacts with proteins that influence synaptic plasticity and vesicle trafficking such as synaptophysin and synapsin to support efficient synaptic signaling.\u003cbr\u003e\nAbnormalities in MYO5A are associated with Griscelli syndrome type 1 and neurological disorders. Griscelli syndrome type 1 involves defects in the MYO5A protein disrupting melanosome transport and leading to pigmentary dilution. In neurological disorders the protein's connection with synaptic function makes it relevant for conditions linked to impaired neurotransmitter distribution. MYO5A's interaction with Rab27A is important for both pigmentation and proper synaptic vesicle transport tying it to the pathological features observed in these disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854247645353,"sku":"ab235003","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab235003","provider":"Iright","version":"1.0","type":"link"}