{"product_id":"abcam-ab235338","title":"Abcam, ab235338, Anti-PIGX antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal PIGX antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PIGX aa 1-250.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human PIGX aa 1-250. The exact immunogen used to generate this antibody is proprietary information.Q8TBF5\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity \u0026gt;95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPIGX also known as phosphatidylinositol glycan anchor biosynthesis class X functions as a subunit in the glycosylphosphatidylinositol (GPI) anchor biosynthesis pathway. PIGX has a mass of approximately 25 kDa and shows expression in various tissues including the liver and kidney. This protein participates in the early step of GPI anchor formation specifically involved in anchoring proteins to membranes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis target is essential in the complex that initiates GPI anchor biosynthesis. PIGX partners with PIG-A PIG-C and other components to catalyze the transfer of N-acetylglucosamine to phosphatidylinositol a critical step in the production of GPI anchors. These anchors tether proteins to the cell surface impacting processes such as signal transduction cell adhesion and protein sorting.\u003cbr\u003e\nPathways\u003cbr\u003e\nPIGX plays a significant role in the GPI-anchor biosynthesis pathway and glycosylation. Within these pathways PIGX closely interacts with other GPI biosynthesis proteins such as PIG-M and PIG-L coordinating the sequential steps necessary for anchor formation. This pathway ensures that proteins anchor properly to cell membranes influencing cellular communication and immune responses.\u003cbr\u003e\nDefects in PIGX can lead to conditions like paroxysmal nocturnal hemoglobinuria (PNH) and inherited GPI deficiency (IGD). PNH manifests due to mutations affecting GPI anchor synthesis which also involves the PIG-A protein. Additionally issues in the GPI biosynthesis pathway where PIGX is integral can result in neurologic disorders and developmental delays linked to IGD. Understanding PIGX's role aids in diagnosing and developing therapies for these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854255476905,"sku":"ab235338","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab235338","provider":"Iright","version":"1.0","type":"link"}