{"product_id":"abcam-ab235569","title":"Abcam, ab235569, Pimasertib (AS-703026), MEK1\/2 inhibitor","description":"\u003cp\u003eSize: 5mg\u003cbr\u003e\nMW 431.2 Da, Purity \u0026gt;98%. Pimasertib (AS-703026) is a potent and selective ATP non-competitive inhibitor of MEK1 and MEK2. It displays an IC 50  of 5 nM-2 μM in multiple myeloma cell lines. Growth and survival of U-266 and INA-6 is inhibited with IC 50  of 5 nM and 11 nM, respectively. Induces apoptosis via caspase-3 and PARP cleavage in multiple myeloma cells. Inhibits the ERK pathway, proliferation, and transformation in human DLD-1 colorectal cancer cells what carry the D-MUT mutant allele of K-Ras.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:1204531-26-9,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:431.2 Da,\u003cbr\u003e\nMolecular formula:C15H15FIN3O3,\u003cbr\u003e\nPubChem:44187362,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:DMSO 86 mg\/mL (199.44 mM)Insoluble in water and ethanol,\u003cbr\u003e\nBiochemical name:Pimasertib,\u003cbr\u003e\nBiological description:Pimasertib (AS-703026) is a potent and selective ATP non-competitive inhibitor of MEK1 and MEK2. It displays an IC50 of 5 nM-2 μM in multiple myeloma cell lines. Growth and survival of U-266 and INA-6 is inhibited with IC50 of 5 nM and 11 nM, respectively. Induces apoptosis via caspase-3 and PARP cleavage in multiple myeloma cells. Inhibits the ERK pathway, proliferation, and transformation in human DLD-1 colorectal cancer cells what carry the D-MUT mutant allele of K-Ras.,\u003cbr\u003e\nCanonical smiles:C1=CC(=C(C=C1I)F)NC2=C(C=CN=C2)C(=O)NCC(CO)O,\u003cbr\u003e\nIsomeric smiles:C1=CC(=C(C=C1I)F)NC2=C(C=CN=C2)C(=O)NC[C@@H](CO)O,\u003cbr\u003e\nInChi:InChI=1S\/C15H15FIN3O3\/c16-12-5-9(17)1-2-13(12)20-14-7-18-4-3-11(14)15(23)19-6-10(22)8-21\/h1-5,7,10,20-22H,6,8H2,(H,19,23)\/t10-\/m0\/s1,\u003cbr\u003e\nInChiKey:VIUAUNHCRHHYNE-JTQLQIEISA-N,\u003cbr\u003e\nIUPAC Name:N-[(2S)-2,3-dihydroxypropyl]-3-(2-fluoro-4-iodoanilino)pyridine-4-carboxamide\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called B1698 Pimasertib. B1698-25 is the same size as the 25 mg size of ab235569.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-It is important to note that this is air sensitive and impurities can occur as a result of air oxidation, Store in the dark, Store under desiccating conditions\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847503138985,"sku":"ab235569","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab235569","provider":"Iright","version":"1.0","type":"link"}