{"product_id":"abcam-ab236146","title":"Abcam, ab236146, Anti-HSPA12A antibody [EPR16763] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal HSPA12A antibody. Carrier free. Suitable for IP, WB, ICC\/IF, IHC-P and reacts with Human, Mouse, Rat samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR16763,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:ICC\/IF, IP, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab236146 is the carrier-free version of\u003cbr\u003e\nab200838\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nHSPA12A also known as Heat Shock Protein Family A (Hsp70) Member 12A is a member of the Hsp70 family of proteins involved in stress response. This protein has an approximate molecular mass of 80 kDa. HSPA12A shows expression predominantly in endothelial cells where it plays a significant role. Like other Hsp70 proteins it assists in protein folding assembly and transport within cells. HSPA12A's activity supports the maintenance of cellular proteostasis under stress conditions facilitating correct protein conformation and preventing aggregation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nHSPA12A participates in processes that maintain vascular homeostasis. It may be involved in a complex with other Hsp70 proteins to provide cellular protection against various stressors. The precise composition and roles of these complexes remain under investigation. Its activity as a molecular chaperone helps protect cells from apoptosis and supports the repair of damaged proteins which is important for normal cell function and survival in stressful environments.\u003cbr\u003e\nPathways\u003cbr\u003e\nHSPA12A is involved in key pathways related to cellular stress responses and cytoprotection. It interacts with signaling pathways such as the unfolded protein response and the oxidative stress response. These pathways include interactions with other chaperone proteins like Hsp90 that facilitate cellular adaptation to adverse conditions. Its involvement in these pathways suggests that HSPA12A plays a role in regulating cellular stress mechanisms and promoting recovery after stress exposure.\u003cbr\u003e\nHSPA12A appears to have a connection to cardiovascular diseases and certain neurodegenerative disorders. In cardiovascular diseases its expression in endothelial cells suggests it may contribute to vascular integrity and function. Furthermore HSPA12A may have connections to neurodegenerative disorders as it assists in protecting neurons from protein aggregation and apoptosis. These links might involve interactions with proteins like alpha-synuclein where its chaperone role could influence the disease progression. Understanding these relationships could provide new insights into therapeutic strategies targeting these disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851641966761,"sku":"ab236146","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab236146","provider":"Iright","version":"1.0","type":"link"}