{"product_id":"abcam-ab236608","title":"Abcam, ab236608, Anti-APH antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal APH antibody. Suitable for WB, IHC-P, ICC\/IF and reacts with Human, Mouse samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human APEH aa 200-500.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:ICC\/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human APEH aa 200-500. The exact immunogen used to generate this antibody is proprietary information.P13798\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity \u0026gt;95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe target protein APH also known as Aminoglycoside Phosphotransferase or APH(2\") serves a critical role in antibiotic resistance mechanisms by phosphorylating aminoglycoside antibiotics leading to inactivation. APH with a mass of approximately 31 kDa can be found in bacteria that are often resistant to several antibiotics. Although mainly located in prokaryotes certain modified forms also show expression in eukaryotic systems for research purposes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nAPH plays a significant role in cell survival by protecting bacteria from antibiotic stress a process necessary for maintaining membrane integrity under antibiotic pressure. This enzyme is not a part of a larger protein complex but exhibits highly specific interactions with aminoglycosides. It commonly associates with resistance mechanisms allowing bacteria to survive in otherwise lethal environments.\u003cbr\u003e\nPathways\u003cbr\u003e\nAPH significantly impacts aminoglycoside metabolic pathways and contributes to the overarching antibiotic resistance pathway. This phosphotransferase action is often coordinated alongside AAC (Aminoglycoside N-acetyltransferase) and ANT (Aminoglycoside O-nucleotidyltransferase) proteins. They collectively enable bacteria survival by modifying antibiotics preventing their effective binding to bacterial ribosomal targets.\u003cbr\u003e\nAPH presents a considerable threat due to its association with multidrug-resistant bacterial infections and urinary tract infections. The protein's role in resistance complicates treatment protocols and is integrated into bacterial adaptation strategies. Alongside proteins like AAC and ANT APH contributes to bacterial resilience making it a target of interest in studies focused on developing novel antibacterial treatments.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854237716649,"sku":"ab236608","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab236608","provider":"Iright","version":"1.0","type":"link"}