{"product_id":"abcam-ab236726","title":"Abcam, ab236726, Anti-Claudin 20 antibody","description":"\u003cp\u003eSize: 100µg \/ 100µL\u003cbr\u003e\nRabbit Polyclonal Claudin 20 antibody. Suitable for WB, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CLDN20 aa 1-100.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human CLDN20 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.P56880\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity \u0026gt;95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nClaudin 20 also known as CLDN20 is a protein that functions as a structural component in tight junctions. Claudins are a group of proteins important for the maintenance of cell polarity and barrier function in epithelial and endothelial cell layers. Claudin 20 has a low molecular weight of approximately 23 kDa. This protein is predominantly expressed in the kidney lung and intestines indicating its functional significance in these organs.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nClaudin 20 contributes to the paracellular transport by creating selective permeability barriers between epithelial cells. It associates with other claudin proteins to form tight junction strands within the cellular structure. These strands regulate the passage of ions and small molecules thereby maintaining the homeostasis of tissues. The protein often interacts with ZO-1 which is a tight junction-associated protein to stabilize its position within the junction.\u003cbr\u003e\nPathways\u003cbr\u003e\nClaudin 20 plays an integral role in the epithelial barrier function pathway. It is central in maintaining the integrity and permeability of epithelial barriers working alongside proteins such as claudin 1 and claudin 4. It also contributes to the developmental and maintenance aspects of tight junctions participating in the signaling pathways that control cellular adhesion and communication. Alterations in these pathways can lead to varied physiological responses.\u003cbr\u003e\nClaudin 20 has been implicated in certain kidney disorders such as nephrotic syndrome due to its role in maintaining the glomerular filtration barrier. It also relates to lung diseases like pulmonary fibrosis where tight junction integrity is compromised. Claudin 20 interacts with other claudin proteins such as claudin 16 in the development and progression of these conditions highlighting its significant role in disease pathology.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854227919017,"sku":"ab236726","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab236726","provider":"Iright","version":"1.0","type":"link"}