{"product_id":"abcam-ab237509","title":"Abcam, ab237509, Anti-Intersectin-2 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal Intersectin-2 antibody. Suitable for WB, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ITSN2 aa 900-1250.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human ITSN2 aa 900-1250. The exact immunogen used to generate this antibody is proprietary information.Q9NZM3\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity greater than 95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nIntersectin-2 also known as ITSNT2 is a multi-domain scaffold protein involved in endocytosis and signal transduction. It has a molecular mass of approximately 194 kDa. Intersectin-2 helps form dynamic protein complexes by acting as an adaptor facilitating protein-protein interactions. This protein mainly expressed in the nervous system enabling synaptic vesicle recycling important for neurotransmission. It contains multiple EH (Eps15 Homology) domains SH3 (Src homology 3) domains and a coiled-coil domain all contributing to its versatile binding capabilities.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe sophisticated molecular architecture of Intersectin-2 allows it to participate in essential cellular processes like endocytosis and actin cytoskeleton remodeling. It functions by interacting with proteins such as Dynamin Eps15 and Synaptojanin forming complexes necessary for clathrin-mediated endocytosis. Moreover its presence in the nervous system is significant for neuronal communication and plasticity by influencing synaptic vesicle trafficking and recycling. This activity highlights its role in modulating excitatory and inhibitory signals at synapses.\u003cbr\u003e\nPathways\u003cbr\u003e\nIntersectin-2 plays an important role in the endocytic pathways and is a part of the Ras-MAPK signaling cascade. In the endocytic pathway Intersectin-2 interacts with several proteins like Clathrin and AP-2 complex facilitating vesicle formation and internalization of receptor-ligand complexes. In the Ras-MAPK signaling pathway it may regulate downstream signaling events by interacting with components such as SOS influencing cell growth and differentiation. These interactions link it to broader cellular processes like receptor-mediated signaling and cell survival.\u003cbr\u003e\nMalfunction of Intersectin-2 links to neurological conditions such as Alzheimer's disease and epilepsy. In Alzheimer's disease altered Intersectin-2 expression correlates with dysfunctional endocytic activity and synaptic failure key features in disease progression. Furthermore in epilepsy interactions with proteins like Dynamin and Synaptojanin imply that disruptions in Intersectin-2's function may affect neuronal excitability and neurotransmitter release. Understanding these associations provides insights into potential therapeutic targets for these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854093308073,"sku":"ab237509","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab237509","provider":"Iright","version":"1.0","type":"link"}