{"product_id":"abcam-ab237680","title":"Abcam, ab237680, Anti-TMEM174 antibody","description":"\u003cp\u003eSize: 100µg \/ 100µL\u003cbr\u003e\nRabbit Polyclonal TMEM174 antibody. Suitable for WB, IHC-P, ICC\/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Transmembrane protein 174 aa 50 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:WB, IHC-P, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human Transmembrane protein 174 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q8WUU8\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity greater than 95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTMEM174 also known as Transmembrane Protein 174 is an integral membrane protein with a mass of approximately 37 kDa. It exhibits expression in several tissues with higher levels observed in the bladder brain and kidney. Structurally TMEM174 is characterized by multiple transmembrane domains which suggests its potential role in cellular signaling or transport processes across the membrane.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTMEM174 functions as part of cellular processes that involve ion transport and signal transduction. Although not a component of any well-characterized protein complex its positioning within the membrane and expression profile indicate a supportive role in maintaining cellular homeostasis and possibly in response to extracellular signals. Current studies continue to explore its comprehensive biological roles and interactions.\u003cbr\u003e\nPathways\u003cbr\u003e\nResearchers have linked TMEM174 to regulation within the ion transport and cellular signaling pathways. There is evidence that TMEM174 may interact with proteins like SLC family transporters which suggests its participation in maintaining cellular ion balance. This positioning implicates TMEM174 in influencing cellular communication processes though more research is necessary to fully define its pathway roles.\u003cbr\u003e\nScientists are examining TMEM174's potential involvement in conditions like neurodegenerative disorders and kidney dysfunction. Correlations have been observed with proteins such as Tau in the context of neurodegeneration though the mechanisms remain not yet well understood. TMEM174's expression patterns and interactions indicate it could be a target for future therapeutic interventions highlighting the need for further study in various disease contexts.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854189220009,"sku":"ab237680","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab237680","provider":"Iright","version":"1.0","type":"link"}