{"product_id":"abcam-ab238676","title":"Abcam, ab238676, Anti-NOD1 antibody [EPR20833] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal NOD1 antibody. Carrier free. Suitable for WB and reacts with Mouse samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR20833,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab238676 is the carrier-free version of\u003cbr\u003e\nab215726\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nNOD1 also known as nucleotide-binding oligomerization domain-containing protein 1 is a protein that plays a role as a recognition receptor within the immune system. It has an approximate mass of 103 kDa and is expressed in various tissues including the gastrointestinal tract and epithelial cells. NOD1 functions by detecting specific molecules from bacterial cell walls specifically diaminopimelic acid leading to the activation of immune responses. Through its interaction with bacterial peptidoglycans NOD1 plays an important function in the innate immune defense against pathogens.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nNOD1 is involved in sensing bacterial infections and initiating immune responses. It participates as part of the NOD-like receptor (NLR) family contributing significantly to inflammatory signal transduction. Upon recognition of bacterial components NOD1 triggers signaling cascades that result in the activation of NF-κB leading to the production of pro-inflammatory cytokines. By orchestrating these molecular events NOD1 plays a role in maintaining homeostasis and responding to microbial threats which influences various immune-related processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nNOD1 is integral to the immune signaling pathway involving inflammation and cellular defense. It is associated with the NF-κB signaling pathway and MAPK pathway important in mounting an effective immune response. NOD1 interaction with RIPK2 a kinase protein facilitates downstream activation of these pathways enhancing cytokine production and strengthening the body's defense mechanisms. These pathways enable NOD1 to communicate intracellularly and coordinate responses essential for pathogen clearance.\u003cbr\u003e\nNOD1 has associations with inflammatory bowel disease (IBD) and asthma. Variants or dysregulations of NOD1 contribute to the susceptibility and pathology of these conditions. Within these disorders NOD1 activity can influence other proteins involved in inflammatory processes such as RIPK2 which acts synergistically to mediate immune responses. Understanding NOD1’s connection to these diseases may lead to therapeutic strategies targeting its signaling cascades to mitigate inflammation and disease progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852286283945,"sku":"ab238676","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab238676","provider":"Iright","version":"1.0","type":"link"}