{"product_id":"abcam-ab238901","title":"Abcam, ab238901, Anti-MICAL2 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal MICAL2 antibody. Suitable for IHC-P, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MICAL2 aa 1-500.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human MICAL2 aa 1-500. The exact immunogen used to generate this antibody is proprietary information.O94851\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity greater than 95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMICAL2 or Microtubule Associated Monooxygenase Calponin and LIM Domain Containing 2 is a multifunctional enzyme with a molecular weight of about 128 kDa. It plays a role in redox reactions and cytoskeletal dynamics by regulating actin filament depolymerization. This protein expresses predominantly in the nervous system and various cancerous tissues. MICAL2 has a unique and functional domain architecture which comprises flavoprotein monooxygenase calponin homology LIM domain and a C-terminal coiled-coil domain.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMICAL2 influences cytoskeletal restructuring by acting on actin dynamics through its monooxygenase activity. It is not typically part of a stable multi-protein complex but interacts transiently with other proteins to carry out its functions. The protein contributes to cellular processes like axon guidance cellular motility and neuronal differentiation. It is vital in remodeling cell structure playing a significant role in signal transduction cascades that govern cell shape and movement.\u003cbr\u003e\nPathways\u003cbr\u003e\nMICAL2 participates in the Semaphorin signaling pathway and is also involved in the signaling pathways related to cell adhesion and migration. Within these pathways it acts closely with proteins like Plexins which are receptor proteins influencing actin filament modulation. This partnership affects processes like axon steering and cellular response to environmental cues enhancing understanding of neuron navigation and tumor invasion.\u003cbr\u003e\nMICAL2 shows significant relevance to cancer progression notably in melanoma and colorectal cancer. The elevated expression of MICAL2 correlates with enhanced metastatic behavior linking it to cancer proliferation and invasion. Additionally its interaction with other cancer-associated proteins such as those in the Plexin family helps explain its role in oncogenic processes. These associations highlight its potential as a biomarker or therapeutic target in oncological research.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854078234793,"sku":"ab238901","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab238901","provider":"Iright","version":"1.0","type":"link"}