{"product_id":"abcam-ab239857","title":"Abcam, ab239857, Anti-TIL\/TLR1 antibody [EPR2075] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal TIL\/TLR1 antibody. Carrier free. Suitable for IP, Flow Cyt, WB and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR2075,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IP, Flow Cyt, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab239857 is the carrier-free version of\u003cbr\u003e\nab68158\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nToll-like receptor 1 (TLR1) also known as TIL plays a significant role in the immune system. It is a pattern recognition receptor that detects pathogen-associated molecular patterns (PAMPs). TLR1 has a molecular weight of approximately 90 kilodaltons. It is expressed on the surface of various immune cells including monocytes macrophages and dendritic cells. TLR1 recognizes triacylated lipopeptides in combination with TLR2 forming a heterodimer that is essential for signaling. This interaction enhances the immune response against microbial infections.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTLR1 contributes to the immune response by participating in the detection of bacterial lipoproteins. This receptor is a part of the Toll-like receptor family which plays an essential role in innate immunity. TLR1 often in complex with TLR2 helps in recognizing and responding to the structural motifs of microbial pathogens. These interactions lead to the activation of downstream signaling pathways triggering the production of cytokines and other mediators essential for inflammatory responses.\u003cbr\u003e\nPathways\u003cbr\u003e\nTLR1 is involved in the Toll-like receptor signaling pathway and the NF-kB signaling pathway. In the Toll-like receptor pathway TLR1-TLR2 heterodimers signal through adaptor proteins like MyD88 which leads to the activation of transcription factors such as NF-kB. This mechanism regulates the expression of genes involved in immune and inflammatory responses. TLR1 coordinates with TLR2 not just in recognition of ligands but also in the signaling to produce a coordinated immune response enhancing the cell's ability to deal with infections.\u003cbr\u003e\nTLR1 plays a role in conditions involving immune dysregulation such as tuberculosis and sepsis. Genetic variations in TLR1 can impact susceptibility to these diseases by altering the receptor's ability to recognize pathogenic components. TLR1's interaction with TLR2 influences the inflammatory response and may contribute to inappropriate immune activation seen in sepsis. These receptors' roles in inflammation and pathogen recognition highlight their importance in understanding the development and progression of immune-related diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851928522921,"sku":"ab239857","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab239857","provider":"Iright","version":"1.0","type":"link"}