{"product_id":"abcam-ab239981","title":"Abcam, ab239981, Anti-OS9 antibody [EPR4272(2)] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal OS9 antibody. Carrier free. Suitable for IHC-P, WB and reacts with Mouse, Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR4272(2),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab239981 is the carrier-free version of\u003cbr\u003e\nab109510\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nOS9 also known as osteosarcoma amplified 9 protein has a molecular mass of approximately 84 kDa. The protein primarily locates in the endoplasmic reticulum (ER). OS9 functions as an ER-associated protein that plays an important role in the recognition and targeting of misfolded glycoproteins for degradation through the ER-associated degradation (ERAD) pathway. It assembles as part of the ERAD machinery through interactions with glycoproteins via its mannose 6-phosphate receptor homology (MRH) domain directly influencing the fate of proteins that fail proper folding.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nOS9 plays an important role in protein quality control within the cell. It forms part of a complex that detects and binds misfolded glycoproteins therefore marking them for transport to the proteasome for degradation. This function aids in maintaining cellular homeostasis by preventing the accumulation of defective proteins that can lead to cellular stress and dysfunction. The protein works in coordination with other ER chaperones and components such as SEL1L and HERPUD1 facilitating efficient substrate delivery to the degradation pathway.\u003cbr\u003e\nPathways\u003cbr\u003e\nOS9 integrates into the ERAD pathway which is important for managing the protein folding load within the ER. This process is essential in managing and mitigating ER stress linked to the unfolded protein response (UPR). In particular OS9 interacts with ER mannosyl-oligosaccharide 12-alpha-mannosidase (MAN1B1) to trim mannose a vital step in determining protein fate within this pathway. Additionally OS9 links with proteins such as XBP1 helping regulate cellular stress responses.\u003cbr\u003e\nOS9 has implications in neurodegenerative diseases and cancer. Misregulation or mutations affecting its function can contribute to diseases characterized by protein misfolding such as Alzheimer's disease where it might interact with other proteins involved in amyloid precursor protein (APP) processing. Additionally in the context of cancer overexpression correlates with tumor progression in certain cancers as it may influence pathways involving HERPUD1 affecting cell survival and proliferation under stress conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851807477929,"sku":"ab239981","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab239981","provider":"Iright","version":"1.0","type":"link"}