{"product_id":"abcam-ab242087","title":"Abcam, ab242087, Anti-AGPAT7 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal AGPAT7 antibody. Suitable for IP and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human LPCAT4 aa 450 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human LPCAT4 aa 450 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q643R3\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Antibody was affinity purified using an epitope specific to AGPAT7 immobilized on solid support., Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAGPAT7 also known as 1-acylglycerol-3-phosphate O-acyltransferase 7 is an enzyme that plays a role in lipid biosynthesis by converting lysophosphatidic acid (LPA) into phosphatidic acid (PA). This enzyme has a molecular mass of approximately 37 kilodaltons (kDa). In terms of its expression profile AGPAT7 can be found in various tissues including the liver and adipose tissue suggesting its involvement in lipid metabolism across different biological systems.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis protein is associated with the membrane of the endoplasmic reticulum where it is responsible for the acylation step in the glycerolipid biosynthesis pathway. AGPAT7 does not form part of a larger complex but acts in concert with other enzymes involved in lipid production. Its ability to catalyze the acylation process marks its significance in synthesizing a wide range of lipid molecules impacting membrane composition and signaling pathways.\u003cbr\u003e\nPathways\u003cbr\u003e\nAGPAT7 is directly involved in the glycerophospholipid metabolism pathway which is a component of the broader lipid metabolic process. It also contributes to the phosphatidic acid biosynthesis pathway linking it to other key players such as AGPAT2 and LPAAT which function together in regulating lipid intermediates and ensuring the steady production of phosphatidic acid a precursor for triglycerides and phospholipids.\u003cbr\u003e\nAGPAT7's role in lipid biosynthesis has implications for metabolic diseases such as obesity and metabolic syndrome. Alterations in AGPAT7 expression might disrupt lipid homeostasis potentially leading to these conditions. Moreover its connection to AGPAT2 known for its involvement in congenital generalized lipodystrophy highlights the enzyme's importance in maintaining lipid balance. Understanding AGPAT7's function in these contexts might offer new insights into therapeutic approaches for lipid-related disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46853977047209,"sku":"ab242087","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab242087","provider":"Iright","version":"1.0","type":"link"}