{"product_id":"abcam-ab244388","title":"Abcam, ab244388, Anti-Density Regulated Protein antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal Density Regulated Protein antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human, Rat, Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human DENR aa 1-100.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WB, IHC-P, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human DENR aa 1-100. The exact immunogen used to generate this antibody is proprietary information.O43583\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe Density Regulated Protein also known as NDRG1 is integral to various cellular processes. It weighs approximately 43 kDa and is encoded by the NDRG1 gene. This protein is widely expressed in many tissues including the liver brain heart and skeletal muscle. NDRG1 shows a specific functional expression in cells undergoing differentiation and stress responses. Researchers have identified its connection with the regulation of cell growth and proliferation leading to its descriptive name.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nDensity Regulated Protein plays an important role in cellular stress responses and differentiation regulation. This protein interacts with various signaling molecules indicating its participation in larger protein complexes. It modulates the cell cycle and is involved in response to hypoxia. It also plays a critical role in inhibiting metastasis showing its importance in maintaining normal cell behavior and suppressing abnormal growth.\u003cbr\u003e\nPathways\u003cbr\u003e\nNDRG1 integrates prominently within the PI3K\/AKT signaling pathway. This pathway is essential for regulation of cell survival metabolism and growth. Within this context the protein interacts with and influences other proteins such as PTEN and mTOR which are key components of the pathway. Moreover it cross-talks with other pathways such as TGF-beta further highlighting its multifaceted roles in cellular dynamics.\u003cbr\u003e\nDensity Regulated Protein is linked to several conditions notably cancer and neurodegenerative diseases. In cancer its expression levels are often altered correlating with tumor suppression and metastasis inhibition. The interaction with p53 a well-known tumor suppressor protein illustrates the significance of NDRG1 in oncology research. Additionally malfunctions of this protein can lead to inherited conditions such as Charcot-Marie-Tooth disease suggesting its essential role in neurological health and integrity.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854182928553,"sku":"ab244388","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab244388","provider":"Iright","version":"1.0","type":"link"}