{"product_id":"abcam-ab246329","title":"Abcam, ab246329, Anti-SLC25A12 antibody [EPR16294] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal SLC25A12 antibody. Carrier free. Suitable for IP, WB and reacts with Human, Mouse, Rat samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR16294,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab246329 is the carrier-free version of\u003cbr\u003e\nab200201\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSLC25A12 also known as the mitochondrial aspartate\/glutamate carrier 1 (AGC1) functions as a transporter protein. It facilitates the exchange of aspartate and glutamate across the inner mitochondrial membrane. This protein has a molecular mass of approximately 77 kDa. SLC25A12 is mainly found in tissues with high metabolic activity including the brain heart and skeletal muscle.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSLC25A12 plays an important role in energy metabolism. It is involved in transferring aspartate from the mitochondria to the cytosol and glutamate in the opposite direction which is essential for the malate-aspartate shuttle. This carrier contributes significantly to maintaining the balance of cellular metabolism by linking the citric acid cycle and amino acid synthesis to mitochondrial energy production. SLC25A12 operates as part of a larger complex of mitochondrial transport proteins which facilitate similar exchanges.\u003cbr\u003e\nPathways\u003cbr\u003e\nSLC25A12 is vitally linked to the malate-aspartate shuttle and the urea cycle. In the malate-aspartate shuttle it works closely with other proteins including SLC25A13 (AGC2) to maintain NADH\/NAD+ balance across the mitochondrial membrane. This balance is important for continuous ATP production during oxidative phosphorylation. The function of SLC25A12 in these pathways highlights its significance in both energy metabolism and nitrogen disposal processes interlinking with proteins involved in these metabolic pathways.\u003cbr\u003e\nMutations and altered expression of SLC25A12 have been associated with neurological conditions such as autism and epilepsy. Research shows a correlation between SLC25A12 dysfunction and disrupted energy metabolism in neurons which may contribute to the pathophysiology of these conditions. Furthermore interaction with proteins like SLC25A13 has been observed in some metabolic disorders emphasizing the interconnected nature of metabolic pathways and their role in disease.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855992082601,"sku":"ab246329","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab246329","provider":"Iright","version":"1.0","type":"link"}