{"product_id":"abcam-ab246859","title":"Abcam, ab246859, Anti-MYOM2 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal MYOM2 antibody. Suitable for IHC-P, ICC\/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human MYOM2 aa 1-200.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human MYOM2 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.P54296\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMYOM2 also known as myomesin-2 is a protein involved in muscle structure and function. It has a molecular mass of roughly 166 kDa. This protein is predominantly expressed in cardiac and skeletal muscle tissues. MYOM2 plays an important mechanical role by contributing to the M-line of the sarcomere which is essential for muscle elasticity and contractility acting as a link between myosin thick filaments and other structural proteins within the muscle cell.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMYOM2 integrates into the sarcomeric M-band complex. This complex is important for maintaining the structural integrity of myofibrils. MYOM2 stabilizes interactions between the thick filament protein myosin and other M-band proteins such as myomesin-1 and myomesin-3. This stabilization supports muscle contraction processes and overall muscle fiber architecture adapting muscle cells to mechanical stress.\u003cbr\u003e\nPathways\u003cbr\u003e\nMYOM2 is involved in muscle contraction and structural organization pathways. Specifically it plays a part in the myofibril assembly pathway where it collaborates with other proteins like titin and myosin binding protein C to ensure proper sarcomere assembly. These interactions help maintain the functional properties of muscle tissues contributing to force generation and transmission across muscle cells.\u003cbr\u003e\nMYOM2 has associations with muscle-related diseases particularly hypertrophic cardiomyopathy (HCM). This disease impacts cardiac muscle and is linked with mutations or variations in MYOM2 and related proteins such as myomesin-1 and titin. Additionally MYOM2 may contribute to myofibrillar myopathy a disorder characterized by disorganization of myofibrils within muscle cells where changes in its structure can disrupt muscle function.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854092488873,"sku":"ab246859","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab246859","provider":"Iright","version":"1.0","type":"link"}