{"product_id":"abcam-ab246924","title":"Abcam, ab246924, Anti-GAS2L1 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal GAS2L1 antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human GAS2L1 aa 450-600.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WB, IHC-P, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human GAS2L1 aa 450-600. The exact immunogen used to generate this antibody is proprietary information.Q99501\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe growth arrest-specific 2 like 1 protein known as GAS2L1 also goes by the name GAS2-related protein on the basis of its homology with the GAS2 family. This protein weighs approximately 81 kDa and is expressed in human tissues particularly skeletal muscle and heart. Structurally GAS2L1 contains calponin homology domains which suggest its involvement in cytoskeletal interactions. The calponin homology domains in GAS2L1 play a role in binding to actin and microtubules indicating its importance in cellular structural stability.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGAS2L1 interacts with elements fundamental to cytoskeletal organization actively contributing to the maintenance of cellular mechanics. GAS2L1 is not classified as a part of a larger protein complex but operates in coordination with cytoskeletal elements such as actin filaments. The protein helps ensure the proper function of the cytoskeleton important for cell shape mobility and division. Its expression in muscle tissues suggests a role in functions unique to these tissue types.\u003cbr\u003e\nPathways\u003cbr\u003e\nGAS2L1 plays a role in cellular structural dynamics and integrity particularly through the regulation of cytoskeletal elements. It links to the actin polymerization pathway which is essential for various cellular processes like movement and division. GAS2L1 interacts with proteins like actin and tubulin emphasizing its role in stabilizing cellular architecture. These interactions can affect cellular signaling pathways that control cell growth and morphology.\u003cbr\u003e\nAltered expression or dysfunction of GAS2L1 associates with cardiomyopathies given its high expression in cardiac muscle. Studies also indicate a potential association between GAS2L1 and skeletal muscle disorders where disruptions in cytoskeletal arrangement contribute to disease. GAS2L1 interacts with actin-related proteins that when dysfunctional may exacerbate the pathogenesis of these diseases. Understanding GAS2L1's role in these contexts may provide insights into therapeutic avenues for related muscular and cardiac conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854077087913,"sku":"ab246924","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab246924","provider":"Iright","version":"1.0","type":"link"}