{"product_id":"abcam-ab248039","title":"Abcam, ab248039, Anti-FLCN antibody [EPNCIR147] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal FLCN antibody. Carrier free. Suitable for WB and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPNCIR147,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab248039 is the carrier-free version of\u003cbr\u003e\nab124885\u003cbr\u003e\nThis antibody was developed as part of a collaboration between the National Cancer Institute's Center for Cancer Research and the lab of Marston Linehan.\u003cbr\u003e\nView antibodies from NCI Center for Cancer Research Collaboration\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe Folliculin (FLCN) protein also known by its gene name BHD serves as a tumor suppressor and has significant roles in cellular processes. FLCN comprises 579 amino acids resulting in a molecular weight of approximately 64 kDa. It expresses in various tissues notably in the skin kidney and lung. FLCN interacts with several proteins and serves essential roles in maintaining cell stability.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nFLCN plays a role in energy and nutrient sensing within cells. It forms part of a complex with FNIP1 and FNIP2 proteins which helps regulate cellular growth and metabolism. This complex acts as a hub for integrating various signaling pathways influencing how cells respond to changing metabolic states.\u003cbr\u003e\nPathways\u003cbr\u003e\nResearch connects FLCN to the mTOR signaling pathway and AMP-activated protein kinase (AMPK) pathway which are critical for cellular metabolism and energy homeostasis. The interaction between FLCN and the mTOR pathway facilitates control over cell growth and proliferation by sensing cellular energy levels. Moreover FLCN associates with pathways that include proteins like TSC1 and TSC2 which also contribute to the regulation of these pathways.\u003cbr\u003e\nFLCN mutations link to Birt-Hogg-Dubé syndrome a genetic disorder causing skin lung and kidney anomalies. Its dysfunction also associates with certain types of kidney cancer where FLCN's tumor suppressor role becomes evident. Altered interactions between FLCN and other proteins such as AMPK can contribute to disease progression highlighting FLCN's importance in medical research concerning cancer and genetic disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851203006633,"sku":"ab248039","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab248039","provider":"Iright","version":"1.0","type":"link"}