{"product_id":"abcam-ab248238","title":"Abcam, ab248238, Anti-GTF2F2 antibody [EPR7584] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal GTF2F2 antibody. Carrier free. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR7584,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab248238 is the carrier-free version of\u003cbr\u003e\nab128945\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGTF2F2 also known as RAP74 forms a critical component of the general transcription factor IIF. It possesses an approximate mass of 74 kDa. This protein ubiquitously expresses in human cells acting as a cofactor within RNA polymerase II transcription machinery. GTF2F2 binds with RNA polymerase II influencing transcription initiation by stabilizing the transcription pre-initiation complex.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGTF2F2 plays a significant role in enhancing the process of transcription elongation. It joins the multi-protein transcription factor IIF complex collaborating with subunits such as TFIIF. GTF2F2's activity is necessary for promoter clearance and efficient RNA synthesis from DNA templates bridging interactions between transcription factors and the polymerase.\u003cbr\u003e\nPathways\u003cbr\u003e\nInvolvement of GTF2F2 is important in the transcriptional regulation pathway. It coordinates with RNA polymerase II and influences the transcription cycle particularly pathways related to transcription elongation. GTF2F2 shares interactions with other transcription-associated proteins including TFIIB and TFIIH which further integrate into these pathways to optimize transcription efficiency and fidelity.\u003cbr\u003e\nStudies link GTF2F2 to neurological disorders including mental retardation. The protein's disruption might alter transcriptional regulation leading to developmental anomalies. In cancer it holds a connection with proteins like p53 where changes in transcription factor activity influenced by GTF2F2 can affect cancer progression or response to treatment through disruption of proper gene expression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851828252841,"sku":"ab248238","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab248238","provider":"Iright","version":"1.0","type":"link"}