{"product_id":"abcam-ab248361","title":"Abcam, ab248361, Anti-Nicalin antibody [EPR8528] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal Nicalin antibody. Carrier free. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR8528,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:This antibody is not suitable for testing tissue samples.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab248361 is the carrier-free version of\u003cbr\u003e\nab131159\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nNicalin also known as NOMO1 is a protein involved in the Notch signaling pathway and has an approximate molecular mass of 70 kDa. This protein localizes predominantly in the endoplasmic reticulum. Nicalin expresses across multiple tissue types but shows higher levels in neural tissues. It interacts with Nomo1 and other proteins to form a multi-protein complex that modulates signaling functions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nNicalin acts as a regulator of Notch signaling an essential pathway for cell differentiation and development. It is a part of Nicalin-Nomo1 complex playing a significant role in modulating protein interactions. This complex contributes substantially to modifying cell fate decisions especially in the nervous system. Nicalin's presence in this complex highlights its importance in fine-tuning signaling mechanisms.\u003cbr\u003e\nPathways\u003cbr\u003e\nNicalin's function strongly influences Notch and Wnt signaling pathways. These pathways are important for processes such as cell proliferation and apoptosis. In the Notch pathway Nicalin forms interactions with the Presenilin protein influencing the maturation of Notch receptor proteins. This interaction affects cellular communication highlighting Nicalin's integrative role within signaling networks.\u003cbr\u003e\nNicalin shows a connection to neurodegenerative diseases like Alzheimer's Disease where its interaction with Presenilin is significant. The protein also relates to developmental disorders influencing nervous system development due to its role in the Notch signaling pathway. Nicalin's regulation within these pathways can impact disease progression and severity indicating its potential as a therapeutic target.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852381343913,"sku":"ab248361","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab248361","provider":"Iright","version":"1.0","type":"link"}