{"product_id":"abcam-ab248410","title":"Abcam, ab248410, Anti-TKTL2 antibody [EPR8592] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal TKTL2 antibody. Carrier free. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR8592,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab248410 is the carrier-free version of\u003cbr\u003e\nab131331\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb\u003cbr\u003e\npatents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4 Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTransketolase-like 2 (TKTL2) also known as TKL2 is an enzyme involved in carbohydrate metabolism. Its molecular weight is approximately 70 kDa. TKTL2 expression occurs broadly in human tissues with reported high expression levels in the heart brain and liver. The enzyme plays an important role in the non-oxidative part of the pentose phosphate pathway where it influences the interconversion of sugar phosphates.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTKTL2 contributes to cellular processes related to energy metabolism and biosynthesis. It forms a functional relationship with other proteins in metabolic pathways participating in the regulation of cellular redox balance and nucleotide biosynthesis. This enzyme supports cellular functions by contributing to the generation of ribose-5-phosphate a precursor for nucleotide synthesis and NADPH essential for anabolic reactions and antioxidative defenses.\u003cbr\u003e\nPathways\u003cbr\u003e\nTKTL2 significantly participates in the pentose phosphate pathway and is implicated in glycolysis connecting to numerous other enzymes like glucose-6-phosphate dehydrogenase. Its activity affects the levels of critical metabolites within these pathways thereby influencing cell survival and proliferation. The interaction of TKTL2 with these pathways highlights its role in regulating cellular metabolic flux impacting processes such as ribonucleotide synthesis and redox homeostasis.\u003cbr\u003e\nTKTL2 has been associated with cancer particularly in tumor progression and metastasis. Aberrant expression of TKTL2 correlates with altered metabolic states within cancer cells linking it to enhanced tumor growth. It is also suggested that TKTL2 might relate to neurodegenerative conditions where its expression aligns with neuronal metabolic demands and oxidative stress resistance. Research also connects TKTL2 with proteins like lactate dehydrogenase in the context of cancer metabolism illustrating the enzyme's relevance in disease states.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851768615081,"sku":"ab248410","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab248410","provider":"Iright","version":"1.0","type":"link"}