{"product_id":"abcam-ab248640","title":"Abcam, ab248640, Anti-PEX7 antibody [EPR7715(2)(B)] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal PEX7 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR7715(2)(B),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab248640 is the carrier-free version of\u003cbr\u003e\nab133754\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPEX7 also known as Peroxisomal Biogenesis Factor 7 functions as a receptor for peroxisomal targeting signal 2 (PTS2). PEX7 has a molecular mass of approximately 39 kDa and localizes primarily in the cytoplasm and peroxisomes of cells. It is abundantly expressed in a variety of tissues including the liver kidney and heart. The expression level suggests that PEX7 plays an important mechanical role in peroxisomal import processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPEX7 facilitates the import of peroxisomal matrix proteins with PTS2 signals by forming a complex with them. This complex guides the proteins to the peroxisome important for maintaining peroxisomal function and integrity. PEX7 interacts with other peroxisomal biogenesis factors such as PEX5 and PEX14 during this process. Proper functioning of PEX7 ensures that enzymes needed for lipid metabolism and other peroxisomal activities are correctly imported to their destination.\u003cbr\u003e\nPathways\u003cbr\u003e\nPeroxisomal protein import involves PEX7 which integrates into broader systems like the peroxisome biogenesis and lipid metabolism pathways. In these pathways PEX7 associates with PEX5 an important player in both pathways facilitating the import of important enzymes for beta-oxidation of fatty acids. Without the proper coordination of these proteins the pathways would falter leading to metabolic irregularities.\u003cbr\u003e\nMalfunction of PEX7 correlates strongly with Rhizomelic Chondrodysplasia Punctata (RCDP) and Zellweger Spectrum Disorders (ZSD). In these conditions PEX7's interaction with proteins like PEX5 becomes compromised leading to impaired peroxisomal protein import and subsequent cellular dysfunction. The dysfunctions highlight the importance of PEX7 in maintaining normal cellular physiology and highlight its relevance in therapeutic research targeting these diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851735126185,"sku":"ab248640","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab248640","provider":"Iright","version":"1.0","type":"link"}