{"product_id":"abcam-ab248642","title":"Abcam, ab248642, Anti-NPY5R antibody [EPR8382] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal NPY5R antibody. Carrier free. Suitable for ICC\/IF, WB, Flow Cyt (Intra) and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR8382,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, Flow Cyt (Intra), ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab248642 is the carrier-free version of\u003cbr\u003e\nab133757\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nNPY5R also known as the Neuropeptide Y receptor Y5 plays an important role in the human body. It is a G-protein-coupled receptor with a molecular weight around 50 kDa. NPY5R is mainly expressed in the central nervous system especially in the hypothalamus. This receptor is one of several receptors that bind to the neuropeptide Y (NPY) peptide YY (PYY) and pancreatic polypeptide (PP) which are involved in various physiological processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nNPY5R influences several important functions related to energy balance and feeding behavior. It is part of the NPY receptor family and works by activating intracellular signaling pathways that affect appetite regulation and energy homeostasis. The receptor's activity can modulate food intake making it an important player in energy metabolism. It does not form part of a protein complex but interacts directly with ligands such as NPY and PYY.\u003cbr\u003e\nPathways\u003cbr\u003e\nNPY5R participates in the neuropeptide signaling pathway and the G-protein-coupled receptor pathway. These pathways significantly impact the regulation of hunger and satiety signals. NPY5R closely interacts with other neuropeptide Y receptors such as NPY1R and NPY2R which together create a network that regulates feeding behavior and body weight. These interactions amplify the receptor's role in the central control of energy balance.\u003cbr\u003e\nNPY5R has a connection to obesity and metabolic syndromes due to its involvement in appetite and energy regulation. Its dysregulation is linked to increased food intake and weight gain. Additionally the receptor has associations with conditions such as anxiety where altered NPY signaling may impact stress responses. NPY and its receptors including NPY5R also relate to other receptors like NPY2R in the modulation of emotional states and metabolic diseases making it a potential target for therapeutic interventions in these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851854532777,"sku":"ab248642","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab248642","provider":"Iright","version":"1.0","type":"link"}