{"product_id":"abcam-ab248697","title":"Abcam, ab248697, Anti-cadherin 10 antibody [EPR5115] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal cadherin 10 antibody. Carrier free. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR5115,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab248697 is the carrier-free version of\u003cbr\u003e\nab134137\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCadherin-10 often referred to as CDH10 is a member of the classical cadherin family which are vital components of calcium-dependent cell-cell adhesion. This protein is approximately 98 kDa in mass. CDH10 is expressed widely in the central nervous system and is also present in other tissues such as the pancreas and kidney. The cadherin family plays a significant role in mediating homophilic interactions between cells influencing tissue architecture and integrity.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCadherin-10 assists in maintaining precise cellular recognition and adhesion. It is particularly involved in the development and maintenance of neural circuits suggesting its involvement in the complexity of brain network formation. Cadherin-10 operates as part of adhesion complexes interacting with cytoplasmic components that link to the actin cytoskeleton thereby influencing cell signaling pathways and cellular communication.\u003cbr\u003e\nPathways\u003cbr\u003e\nCadherin-10 contributes significantly to the Wnt signaling pathway and adherens junction pathways. These pathways are critical for processes such as cellular differentiation migration and organization. Cadherin-10 has related interactions with proteins like beta-catenin within these pathways which facilitates signal transduction and cell structural integrity.\u003cbr\u003e\nAlterations in cadherin-10 can affect neurological and developmental conditions. Mutations or dysregulation of CDH10 have associations with autism spectrum disorders impacting neural communication genes. Similarly changes in cadherin-10 expressions also show connections to manic disorders implying a role in emotional regulation pathways linked to neuropsychiatric proteins such as N-cadherin and synaptic adhesion molecules.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851735257257,"sku":"ab248697","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab248697","provider":"Iright","version":"1.0","type":"link"}