{"product_id":"abcam-ab248732","title":"Abcam, ab248732, Anti-AKAP 95 antibody [EPR8978(B)] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal AKAP 95 antibody. Carrier free. Suitable for IHC-P, ICC\/IF, WB and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR8978(B),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab248732 is the carrier-free version of\u003cbr\u003e\nab134923\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAKAP95 also known as A-kinase anchor protein 95 is a scaffolding protein with a mass of approximately 85-100 kDa. This protein facilitates the localization of protein kinase A (PKA) to specific subcellular compartments optimizing its function. AKAP95 is expressed in the nucleus of various cell types where it participates in organizing and assembling multi-protein complexes. It plays a mechanical role in linking PKA to specific substrates and other signaling molecules which influences cellular processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nAKAP95 integrates into protein complexes that regulate key aspects of cell cycle progression and transcription. It acts in chromatin remodeling which influences gene expression. AKAP95 interacts with several regulatory proteins such as cyclin-dependent kinases to affect cell division. Its role extends to ensuring efficient mitotic entry and chromosome segregation. Through these interactions AKAP95 serves as a central node in the orchestration of nuclear events critical for cell proliferation.\u003cbr\u003e\nPathways\u003cbr\u003e\nAKAP95 operates within signaling networks like the cAMP\/PKA pathway and the cell cycle regulation pathway. Through these pathways it connects intimately with proteins such as PKA and cyclin-dependent kinases. AKAP95 binds to these proteins facilitating the orchestration of phosphorylation events that drive cellular responses to external and internal stimuli. These pathways highlight AKAP95’s connectivity in transducing signals necessary for maintaining cellular homeostasis and proliferation control.\u003cbr\u003e\nAKAP95 shows connections to cancer and cardiac disease. Alterations in its expression and function associate with oncogenic processes involving abnormal cell proliferation commonly seen in cancers. Interactions with proteins like cyclin-dependent kinases highlight its role in tumorigenesis. Additionally dysregulated cAMP\/PKA signaling linked to AKAP95 contributes to cardiac dysfunction. Therefore studying AKAP95 in these contexts provides insight into its potential as a biomarker or therapeutic target in these pathological states.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851744432297,"sku":"ab248732","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab248732","provider":"Iright","version":"1.0","type":"link"}