{"product_id":"abcam-ab248826","title":"Abcam, ab248826, Anti-IMPDH2 + IMPDH1 antibody [EPR9679(B)] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal IMPDH1 antibody. Carrier free. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR9679(B),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab248826 is the carrier-free version of\u003cbr\u003e\nab137112\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe proteins IMPDH2 and IMPDH1 also known as inosine-5'-monophosphate dehydrogenase 2 and 1 are enzymes involved in purine metabolism. IMPDH1 has a mass of approximately 55 kDa while IMPDH2 measures around 56 kDa. Both proteins catalyze the conversion of inosine monophosphate (IMP) to xanthosine monophosphate (XMP) an essential step in the de novo synthesis of guanine nucleotides. They are expressed in various tissues with highest levels found in blood and immune system cells reflecting their important role in cell proliferation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThese enzymes perform critical functions by facilitating the synthesis of guanine nucleotides which are building blocks of DNA and RNA. IMPDH1 and IMPDH2 do not function within large multimeric complexes but exhibit regulatory roles over cellular proliferation and differentiation. The balance between these enzymes impacts the overall guanine nucleotide pool affecting cellular processes such as growth and division.\u003cbr\u003e\nPathways\u003cbr\u003e\nThese enzymes link to nucleotide biosynthesis pathways particularly the guanine nucleotide synthesis pathway. This pathway integrates with the purine metabolism network. IMPDH proteins interact with key enzymes like GMP synthase which directly follows IMPDHs in nucleotide synthesis. Their activity regulates cell proliferative capacity making them integral to processes like DNA replication and repair.\u003cbr\u003e\nThe proteins play significant roles in conditions like cancer and retinitis pigmentosa. IMPDH2 is often overexpressed in rapidly proliferating cancer cells linking it to tumor growth and progression. Meanwhile mutations in IMPDH1 have associations with retinitis pigmentosa a genetic disorder causing retinal degeneration. These enzymes’ dysfunction relates to proteins they interact with in these diseases such as DNA repair proteins in cancer and photoreceptor proteins in retinal disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851887431849,"sku":"ab248826","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab248826","provider":"Iright","version":"1.0","type":"link"}